Itchy swollen bites may be the first sign of a bed bug problem. However, these itchy bites can take as long as 14 days to develop in some people, so it's important to look for other clues if you are concerned about an infestation. Bed bugs typically infest mattresses, box springs, bed frames, and couches. You may be able to find them hiding within the cracks and crevices of beds, furniture, floors, and walls. Bed bugs often leave evidence of small dark stains (fecal droppings) and rusty red spots (bloodstains) on bedding sheets, mattresses, and other areas they hide in or travel along. Heavy bed bug infestations can cause a sweet, musty smell.
Spray all baseboards, loose plaster, behind bed frames and headboards, beneath beds and furniture, and bedsprings and bed frames. Do not apply to furniture surfaces or mattresses where people will be laying or sitting unless using a product labeled for that type of treatment. Infested bedding should not be treated, but should be removed, placed in sealed plastic bags, and taken for laundering and drying at high temperature.
Bed bugs have been pestering humanity for thousands of years, but in the 1950s they finally met their match: the pesticide DDT. Then DDT was banned, but for most of the 40 years since, bed bugs have not been a major problem. Now, however, these blood-sucking vermin are back with a vengeance. That’s the bad news. The good news is that, unlike mosquitoes and ticks, bed bugs don’t spread disease, and there are practical steps you can take to prevent an infestation. And if you do get bed bugs, you can get rid of them yourself. We’ll show you what to look for, how do you get rid of bed bugs if you find them, and how to keep them out!
Pest management professionals are increasingly looking to heat to control bed bugs. Whole houses and, in some cases, multi-unit structures are heated to temperatures well above those lethal to bed bugs, to help assure uniform heating of household contents. Rooms must be heated for several hours during which bulky contents are turned to help ensure heat penetration deep enough to kill bed bugs hiding inside.

Bed bugs are obligatory bloodsuckers. They have mouth parts that saw through the skin, and inject saliva with anticoagulants and painkillers. Sensitivity of humans varies from extreme allergic reaction to no reaction at all (about 20%). The bite usually produces a swelling with no red spot, but when many bugs feed on a small area, reddish spots may appear after the swelling subsides.[15] Bedbugs prefer exposed skin, preferably the face, neck, and arms of a sleeping person.
Bedbugs do, however, have a unique bite pattern. Although some bites may appear alone, most bites occur in a row of three to five bites (termed "breakfast, lunch, and dinner") or in a cluster of red bumps (a rash called bedbug dermatitis). The bites often appear in a zig-zag formation, but may appear in a straight line if the bugs bite you in the morning.
Systematically treat the room–all cracks and crevices around windows, outlets, blinds, pictures, posters and clocks on walls, baseboards, under edges of carpets and any other crevices or void areas in the room. Remember that immature bed bugs are very tiny. Dozens of bed bugs can hide in a recessed screw hole in a bed frame or dresser. Therefore it’s important that no hiding place be overlooked. Treatment can include vacuuming, but should not be limited to vacuuming only. Vacuums do not remove eggs, and will likely not remove all bed bugs from deeply infested cracks and crevices. Vacuums can remove many bed bugs from mattresses and the exterior of box springs (remember to immediately double-bag the vacuum bag after cleaning and dispose of outside in a trash can or dumpster). Sticky tape is another method of picking up bed bugs from furniture, walls, etc.

Bites on dogs and cats will look much like bites on people, and the pet owner may actually suspect a mosquito or flea bit the pet. As with people, bed bugs do not stay on pets, but return to a protected harborage site after feeding. In addition to bites, the presence of the bug’s feces, cast skins and the animal’s irritation at night are also indicators of bed bugs biting pets. Therefore, one of the best things to do is inspect the pet’s bedding and frequently groom the animal while being vigilant for the telltale signs of bed bug presence.
Mattress Encasements:  Mattress encasements are large “fabric bags” that you place a mattress inside. Once zippered closed, any surviving bed bugs will eventually starve. You will need an encasement for each mattress and box-spring in your home. If there are bed bugs in your mattress or box-spring they will start to die within two weeks, inside an encasement, but encasements should be left on for at least a year.There are many types of encasements so it is important to make sure you use an encasement designed for bed bug control. 
An adult bed bug is about 1/5 inch long and 1/8 inch wide. Its reddish brown to mahogany-colored body is greatly flattened and oval shaped. After feeding, the bug's body enlarges considerably, becoming longer and much less flattened. Although the body is covered with tiny hairs, these hairs are so small that they are almost invisible to the naked eye, so the general body appearance is shiny. Bed bugs have piercing-sucking mouthparts that enable them to pierce the skin and suck blood from their hosts.
Seal cracks and crevices between baseboards, on wood bed frames, floors and walls with caulking. Repair or remove peeling wallpaper, tighten loose light switch covers, and seal any openings where pipes, wires or other utilities come into your home. Pay special attention to apartments or rooms that share a wall - bed bugs can move through extremely small gaps to infest new areas.
Track your success. Interceptor cups under your bed posts are also one of the best ways of keeping track of your success with bed bug control. Check the cups regularly and empty into a trash bag or bucket of soapy water.  You may even want to keep track of how many bed bugs you catch weekly so that you can track your success. Wipe out the interceptors and make sure they are clean. Some devices, like the Climbup Interceptor, require redusting with a very small amount of talcum powder to make them slippery again and reduce the bed bug’s chance of escape. Note that talc is not toxic to bed bugs, but simply makes it harder for them to climb out of the cup.  The talc should be barely visible, and more is definitely not better.

In the case of beds, a more economical option is to encase both the mattress and box spring in a protective cover like those used for allergy relief. Encasements specifically designed to help protect against bed bugs are available through retail or pest control firms. Higher quality ones tend to be more durable and comfortable to sleep on. Once the encasement is installed and zipped shut, any bugs which happen to be inside are entombed and eventually will die. Encasements also help protect newly purchased beds, and make it easier to spot and destroy any bugs residing on the outer surface during subsequent examination. Encasements will not, however, keep bed bugs from crawling onto a bed and biting a sleeping person.

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