Some patients develop blisters filled with blood or bloody fluid, especially on the arms and legs. These blood blisters are extremely rare and can burst, causing bleeding or oozing of the bloody fluid. Healthcare providers are not sure if the cause of these blisters is related to the bug or the human but have found groups of patients that were all bitten by bugs on the same train exhibiting this sign.
Prepare the room by separating treated from untreated furniture.  This will involve moving all your furniture to one side of the infested room (Remember, you’ve already assessed which rooms you think are infested.  You may not need to do this in every room).  The process is important because if you treat half of the items in a room and leave other areas untreated, bed bugs may return to the previously treated areas from untreated sites. Take all clothes from drawers, infested closets, etc. and double bag them in clear plastic bags (clear bags are easier to see where things are). Also double bag all personal items (toys, papers, books, electronics, CDs, or anything that could serve as a hiding place for bed bugs) and set them aside until they can be carefully treated, cleaned or inspected. 
The first sign of a bed bug problem is obvious: the bed. After bed bugs feed on humans, they'll leave behind blood stains resembling small rust spots. These will usually be found near the corners and edges of the bed. Bed bugs also shed their skin, or molt, several times as they mature, so you may find their oval brown exoskeletons during your search.
Alternatively, place a bed bug proof mattress cover over an infested mattress to trap the bed bugs inside and starve them to death. This will eliminate the need to purchase a new mattress/boxspring and make treatment and future inspections easier. (Starving the bugs CAN take up to 400 days, so make sure your cover stays sealed for at least that long.)[6]
Pyrethroid sprays are among the stronger and longer-lasting pesticides, but most bed bugs are resistant to these sprays to some degree. Special care should be taken when using pyrethroid sprays, especially when children are present. Only use pyrethroids in places indicated on the label. Do not spray electrical outlets with any type of liquid spray. Spraying should be done when children are not present, and all label directions followed carefully.
Application entails treating all areas where the bugs are found or tend to hide or crawl. This takes considerable effort and follow-ups are usually needed. Companies typically treat seams, folds and crevices of bed components, chairs and sofas, but usually will not spray the entire sleeping surface or seating area. They also do not spray bed sheets, blankets or clothing, which instead should be hot washed or heated in a dryer. 
Insecticides might also have their work cut out for them: Entomologists have known that the common bedbug has built up resistance to some typical insecticides such as those containing certain pyrethroid chemicals like deltamethrin, according to Entomology Today. Deltamethrin apparently paralyzes an insect's nervous system, according to Cornell University.
Reactions to bed bug bites vary among individuals. Many persons show no signs of bites. Others don’t realize they’ve been bitten until redness and swelling appear around the bite, sometimes with intense itching. Some exhibit inflamed swollen spots that may occur in linear series or have a rash-like appearance. Such bite marks, when they appear, may not show for several days after the person is bitten.
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