It's becoming easier to find bed bug mattress covers in local hardware stores. Menard's has one for 24.99 for all sizes. There are others, but beware! Some low quality versions are only plastic, tear easily, and have horrible cheap zippers. The real ones are made of a special fabric and heavy duty zippers. Also when you buy a new mattress, keep the plastic on as well as using a bug cover.
Insecticides are an effective way to eradicate bed bugs, but not the only way. If you or someone in your house is highly sensitive to chemicals, or you’re just not crazy about the idea of spraying chemicals where you sleep, kill the little blood suckers with heat. Temperatures above 120 degrees F kill all stages of bed bugs. Steamers can be used to treat all the same areas where you would have sprayed contact killers. Steamers like the one shown at (top) cost about $150 and are good for many other projects like removing wallpaper, cleaning tile, removing labels, cleaning engine parts and removing wrinkles from fabric.
Wash bedding and clothing (hot water and hot drying cycle for 30–60 minutes), vacuum cracks and crevices, and freeze articles that may have been used as hiding places for bedbugs may reduce infestation until extermination can be performed. Vacuum with special attention to cracks and crevices in furniture, equipment, walls, and floors. Vacuuming some talcum powder will reduce the chance that the bugs will crawl out of the vacuum cleaner. Dispose of the vacuum cleaner filter and bags in a tightly sealed plastic bag.
Bed bugs are very hardy insects. Both adults and nymphs can survive prolonged periods without food or under adverse temperature conditions. Adults can live for a year or longer without feeding and can survive over winter in an unheated building. Nymphs are not as hardy as adults, but they can survive for considerable periods under adverse conditions.
Desiccant dusts.  Two low toxicity dusts with good effectiveness include silica aerogel and diatomaceous earth (DE).  Both of these dusts are low risk to humans, and work by desiccating, or drying out, bed bugs that come in contact with it. Silica aerogel is, in some studies, superior for this purpose.  It is sold under various trade names including Tri-Die™ and CimeXa™.  Diatomaceous earth can also be effective.  Look for DE for insect control–it is not the same product as diatomaceous earth used in swimming pool filters, which is dangerous to breath. Some pest control companies now use desiccant dusts extensively in bed bug control. These relatively inexpensive dust can be purchased online or in garden centers or hardware stores. Look for products labeled for indoor use and lightly dust all accessible crack, crevices and voids.  A paint brush is useful for applying these dusts to seams and crevices in sofas and mattresses, along baseboards and inside drawers and dresssers.
Most bed bug bites go away by themselves and don't need treatment. Keep the skin clean and try not to scratch. Over-the-counter, anti-itching cream for insect bites can help relieve the itching. If the bites are very itchy, your health care provider may prescribe cream or antihistamines to relieve the itchiness. Oral antibiotics may be prescribed for any secondary skin infection from excessive scratching.

Español: matar chinches, Italiano: Liberarsi delle Cimici da Letto, Русский: избавиться от постельных клопов, Deutsch: Bettwanzen loswerden, Français: se débarrasser des punaises de lit, Nederlands: Bedwantsen bestrijden, Čeština: Jak se zbavit štěnic, 中文: 清除床虱, Português: Acabar com os Percevejos, Bahasa Indonesia: Membasmi Kutu Busuk, हिन्दी: खटमलों से छुटकारा पायें, العربية: التخلص من بق الفراش, ไทย: จัดการตัวเรือด, Tiếng Việt: Diệt trừ rệp, 한국어: 빈대 퇴치하는 법, Türkçe: Tahtakurularından Nasıl Kurtulunur, 日本語: トコジラミを退治する
The best method of inspection is always using your body. Bed bugs have to have a blood meal, so if they persist after your treatment, they will find you. If you don't want them biting you and you want to get a good nights rest, then be sure to encase your mattresses, using climb-up bed bug interceptors on your bed frame and post and place Bed Bug Traps around to help monitor bedbug movement.  Replace traps every 90 days.
Isolating your bed from the rest of the house.  If you don’t use a bed, purchase a frame that gets your mattress off the floor and install bed bug interceptors under all feet of the bed frame to keep bed bugs off your bed while you are sleeping. Interceptors are special platforms or cups that are purchased to prevent bed bugs from climbing on to your bed.  An interceptor can be as simple as a sticky card placed under a bed post (sticky and messy).  Better are one of the commercial pitfall traps made specifically for this purpose.  The Climbup™ Bed bug Interceptor and BlackOut BedBug Detector (Google them) are two such products sold online. Relatively inexpensive, these cups trap bed bugs attempting to climb (or exit) the bed. If you have encased your bedding, treated your bed frame thoroughly and installed interceptors, you will be instantly protected against bed bugs.  Don’t take out your clean bedding or put it back on the bed until the bed has been treated (and dried) and encasements installed. And note that for this method to be effective, beds and bedding must not touch the floor, furniture or walls.  This would provide bed bugs other ways to climb onto the bed and foil your defenses.
Perhaps more than any other structural pest, the bed bug illustrates the need for an integrated pest management (IPM) approach. IPM employs not a single method, such as pesticide application alone, but combines several of the best means of control, often adopting less hazardous and more effective pest management. Thus the best bed bug management plans incorporate more than one of the effective control methods listed below.
Mix 3 oz per gallon or 0.75 oz per quart and spray with a low pressure sprayer into the areas where the bed bugs are hiding. Typical areas include bed frames, headboards, under beds, baseboards, moldings, behind pictures,etc. Remember to apply in the joints and crevices of furniture. If the crack and crevice is too small, use an aerosol with a crack and crevice tip (recommendations are below.)

Use of Organic-Based Bed Bug Spray – thanks to growing going green trend, there are now bed bug products made with natural ingredients. With them, you could now get rid of the crawlies safely, easily and inexpensively. However, you should take note that this method only works if you have the best-selling bed bug spray that kills on contact and is without harsh chemical ingredients.
Bedbugs are highly resistant to many sprays. There are, however, certain sprays that may be able to kill bedbugs. Check with a professional exterminator about advice using sprays to try and remove the bedbugs yourself. Dead bedbugs usually won't move, may be arched back, or red in color. Ultimately, you may be better off replacing your mattress and bedding and fumigating your home to kill the bedbugs.
If at all possible, pull up the carpet where it meets the wall and puff powder around the whole perimeter of the room. Inside outlet boxes is a great place to use powders because sprays and electricity don’t mix. Bellow dusters work great for spreading residual insecticide powder. An old makeup brush is a good tool to spread the dust around on hard surfaces. Bed bug powders are available the same places you’ll find the spray pesticides.
Inspection requires knowledge, dedication and time. At minimum an inspection should involve a detailed examination of mattresses, box springs and bed frames, as well as likely hiding places for bed bugs within 20 feet of beds and other places where residents may sleep or rest, e.g., on couches). Clutter-free space will be needed to allow furnishings to be moved and manipulated for inspection. In general, rooms with more furnishings will take more time to inspect. 

To use sprays effectively to eliminate all traces of bed bugs, you need to know the signs of a bed bug infestation. The first sign that you may have bedbugs are some itchy bite marks on your skin when you wake up in the morning. Dr. Carol DerSarkissian on WebMD says that the bites from bed bugs cause red itchy bumps on the skin.3 You can learn about their other signs and symptoms in my articles on what do bed bug bites look like.
Itchy swollen bites may be the first sign of a bed bug problem. However, these itchy bites can take as long as 14 days to develop in some people, so it's important to look for other clues if you are concerned about an infestation. Bed bugs typically infest mattresses, box springs, bed frames, and couches. You may be able to find them hiding within the cracks and crevices of beds, furniture, floors, and walls. Bed bugs often leave evidence of small dark stains (fecal droppings) and rusty red spots (bloodstains) on bedding sheets, mattresses, and other areas they hide in or travel along. Heavy bed bug infestations can cause a sweet, musty smell.
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