One method of applying freezing temperatures to bed bugs entails the use of carbon dioxide (CO2) applied as “snow” with a portable application device, i.e., Cryonite™. When applied directly onto bed bugs, the frozen CO2 will kill them. However, this method is similar to using contact pesticides, that is, there is no residual activity. It can kill only as many bed bugs as the applicator can find. The advantage of using this type of freezing device is that bed bugs may be killed quickly and without the use of more hazardous pesticides. Again, this is not a stand-alone treatment, and it is recommended that it be used as a supplemental to the application of residual pesticides and/or other means of control.

Bedbugs do, however, have a unique bite pattern. Although some bites may appear alone, most bites occur in a row of three to five bites (termed "breakfast, lunch, and dinner") or in a cluster of red bumps (a rash called bedbug dermatitis). The bites often appear in a zig-zag formation, but may appear in a straight line if the bugs bite you in the morning.

Discard affected items. In some cases, infested mattresses and box springs will need to be discarded. Since bed bugs can disperse throughout a building, it also may be necessary to inspect adjoining rooms and apartments. Pay it forward: chop up and/or damage the items you discard so nobody will be tempted to take them home and spread the problem further.[17]

Bed bugs are experts at hiding. Their slim flat bodies allow them to fit into the smallest of spaces and stay there for long periods of time, even without a blood meal. Bed bugs are usually transported from place to place as people travel. The bed bugs travel in the seams and folds of luggage, overnight bags, folded clothes, bedding, furniture, and anywhere else where they can hide. Most people do not realize they are transporting stow-away bed bugs as they travel from location to location, infecting areas as they travel.
Bed bugs tend to congregate, but it’s also common to find a single bug or some eggs here and there. A thorough inspection and treatment may take up to several hours. Some companies use specially trained dogs to assist in finding small dispersed infestations, especially in such places as hotels, schools, libraries and office buildings. When properly trained, bed bug detection dogs can be quite effective. Relatively few companies are routinely using them, however, due to the expense of training and maintaining such animals. Reliability of some of the dogs is also being questioned as more enter the market.    
In a bed bug treatment, alcohol is basically an attempt to fill the role of a contact spray, which is an insecticide spray that kills bed bugs on contact. These sprays are proven to kill at a higher rate than rubbing alcohol could manage, and are extremely versatile in where they can be applied. Pair contact sprays with a couple of residual sprays, and you have a combination of chemicals that will kill bed bugs quickly now, and keep killing over the next few weeks.

Bed bugs are very resilient. Nymphs and adults can persist months without feeding which is unusual for most insects. The ability to survive without a blood meal is longer at cooler temperatures ― potentially up to a year or longer at 55°F or less. In temperature-controlled buildings, a more typical duration is about 2 to 6 months. Consequently, it is usually impractical to leave buildings unoccupied in hopes of ‘starving out’ an infestation. When infested dwellings such as apartments are vacated, bed bugs often disperse to nearby units, or reduce their activity until the unit is reoccupied. 
In the case of beds, a more economical option is to encase both the mattress and box spring in a protective cover like those used for allergy relief. Encasements specifically designed to help protect against bed bugs are available through retail or pest control firms. Higher quality ones tend to be more durable and comfortable to sleep on. Once the encasement is installed and zipped shut, any bugs which happen to be inside are entombed and eventually will die. Encasements also help protect newly purchased beds, and make it easier to spot and destroy any bugs residing on the outer surface during subsequent examination. Encasements will not, however, keep bed bugs from crawling onto a bed and biting a sleeping person.