Stripping and vacuuming the mattresses and box springs, and encasing them.  Double bag your bedding and wash in hot water and dry for at least 30 minutes (discard the inner bag after putting bedding into the washer, as it could have bed bugs).  After vacuuming suspected bed bugs from the bed, take your vacuum cleaner outdoors and remove and discard the bag.  Purchase a good quality set of bed-bug-proof encasements for your mattresses and box springs. Bed bug-proof encasements are fabric sacks into which you slide your mattress or your box spring. The zippers on bed bug encasements are designed to be tight enough to prevent even the smallest life stages of the bed bugs from escaping. Also, good bed bug-proof encasements are woven to prevent bed bugs from biting you through the encasement. A good encasement will trap all bed bugs in the mattress and box spring inside, and will be smooth on the outside, providing few places for bed bugs to hide. Sears, Target, Walmart and other stores may sell bed bug-proof encasements, but these can also be purchased online. A good place to look for different brands and reviews of mattress encasements is Amazon.com (whether you buy there or at a local store). Go to http://www.amazon.com and search for “bed bug mattress protectors”.
They also have the ability to travel beyond the bedroom, so all adjoining rooms should be checked for infestation. Any area that offers a layer of protection, e.g. dark, isolated areas, should be checked. They do leave excrement droppings behind, so even if they are not seen, you can often see where they have been. The best method to find them is to check only at night, and with a red light.
Cracks and crevices of bed frames should also be examined, especially if the frame is wood. (Bed bugs have an affinity for wood and fabric more so than metal or plastic.) Wooden support slats, if present, should be removed and examined since bed bugs often congregate where the ends rest on the frame. Screw holes, knots and other recesses are also common hiding places. Headboards secured to walls should be removed and inspected. In hotels, the area behind the headboard is often the first place that bed bugs become established. Bed bugs also frequently hide within items stored under beds.  

You can make a natural bed bug bite treatment by putting 1 cup distilled water in a spray bottle and adding 10-15 drops tea tree oil. Shake well and spray on areas of skin that have clusters of bed bug bites. Or, you could spray the remedy on a cotton pad and apply to the itchy bumps on your skin. You can also dilutes tea tree oil with a carrier oil, such as coconut oil or sweet almond oil (a few drops of tea tree per one tablespoon of carrier oil).
^ John Southall. "That soon after the Fire of London, in some of the new-built Houses they were observ'd to appear, and were never noted to have been seen in the old, tho' they were then so few, as to be little taken notice of; yet as they were only seen in Firr-Timber, 'twas conjectured they were then first brought to England in them; of which most of the new Houses were partly built, instead of the good Oak destroy'd in the old". A Treatise of Buggs [sic], pp. 16–17. Retrieved 1 December 2016.

Start with the bed, including mattress, box-spring and bed frame. Inspect the visible areas first. Look along all edges and corners.  Also check along all stitch lines and the mattress label. Five sides the mattress can be checked while the mattress is on the bed.  When you are finished checking the upper surfaces, you can then stand the mattress upright so you can check the bottom of the mattress.
Unfortunately standard insect monitors (“sticky traps”) are not very good at trapping bed bugs. To date, the best bed bug trap as measured by cost, ease of use, and effectiveness, is the “Climbup™ Insect Interceptor.” This trap resembles a plastic dish and is placed beneath the legs of beds and other furniture on which persons might relax and serve as “bait” for bed bugs. Bed bugs that climb into the dish are unable to climb its slippery inner surface (which is coated with talcum powder). Studies have shown that even inspections performed by trained and experienced pest management professionals often miss some bed bugs, especially in heavier infestations, and that bed leg traps can catch many of those missed bed bugs.

Apply residual Bed Bug Insecticide Spray. After every crack, crevice, switch plate, electrical switch, baseboard, box springs, mattress, etc, has been treated and everything is put back, it is time for the residual treatment. Using a hand held sprayer such as the Chapin Sure Spray apply Optimate, Cy-Kick, Suspend SC or Demand along the baseboards in the bedroom and closet, under and around the bed, behind the headboard, inside bed stands etc.
To kill bed bugs is to save yourself from a lot of problems. However, before you could eliminate them, there are several preparatory steps that you first have to take so you will know how to get rid of bed bugs. With all those problems and pre-elimination work, many think it is better to prevent the pests by using bed bug spray than to let them in and just get rid of them.

Bed bugs have six life stages from eggs to adulthood. The adults and nymphs of the pests could stay out of sight for months after feeding so they are quite difficult to detect. However, the eggs are much harder to locate. Female bed bugs usually hide them in dark and deep cracks and crevices. The fact that they are very small, makes it even harder to search for them. So, if you need to implement a keen inspection when looking for adult bed bugs, you need to be more canny when looking for their eggs.

Alternatively, place a bed bug proof mattress cover over an infested mattress to trap the bed bugs inside and starve them to death. This will eliminate the need to purchase a new mattress/boxspring and make treatment and future inspections easier. (Starving the bugs CAN take up to 400 days, so make sure your cover stays sealed for at least that long.)[6]
Prior to World War II, bed bug infestations were common. Since the development of synthetic organic insecticides such as DDT and chlordane almost 70 years ago, bed bug infestations in buildings have declined significantly - almost disappeared. In fact, in the United States, bed bug infestations have been exceedingly rare - almost non-existent - until a few years ago.
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Bed bugs like to travel and are good hitchhikers. They will hide in suitcases, boxes and shoes to be near a food supply. They are elusive, nocturnal creatures. They can hide behind baseboards and in cracks, crevices, and folded areas of beds, bedding and adjacent furniture, especially mattresses and box springs. Bed bugs can also hide in electrical switchplates, picture frames, wallpaper and nearly anywhere inside a home, car, bus, or other shelter. Bed bugs usually come out at night for a blood meal. However, they are opportunistic insects and can take a blood meal during the day, especially in heavily-infested areas. Bed bugs usually require 5-10 minutes to engorge with blood. After feeding, they move to secluded places and hide for 5-10 days. During this time in the bed bug life cycle, they do not feed but instead digest their meal, mate, and lay eggs.
Prior to World War II, bed bug infestations were common. Since the development of synthetic organic insecticides such as DDT and chlordane almost 70 years ago, bed bug infestations in buildings have declined significantly - almost disappeared. In fact, in the United States, bed bug infestations have been exceedingly rare - almost non-existent - until a few years ago.
Because bed bugs have become so prevalent in the past few years, many fear they’ll be their next victim. They became so anxious and paranoid of the possible bed bug presence. If you eliminate the pests though, you could have a certain sense of peace knowing that you would not be bothered or bitten them. However, you wouldn’t be able to sleep well for long if you would not kill bed bugs right and continuously do the bed bug preventive steps.
Bring in only what is needed, and avoid sitting or placing coats and other items on beds, floors and sofas where the bugs commonly reside. Essential items can be placed on a tabletop or other hard surface, preferably away from bedrooms and sleeping areas. Better to sit on a hard (non-upholstered) chair than on sofas and recliners. Also try to avoid leaning or brushing against beds and upholstered furniture. If such items are carried out of infested dwellings (e.g., by sanitation workers or firefighters), it’s best to wrap them in plastic or at least not hold them against your body during transport. Emergency Medical (EMS) personnel may need to take additional precautions, such as removing a patient’s bed bug-infested shoes or clothing, or installing plastic sheeting before transporting them in the emergency vehicle.    
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