This question is answered by the condition of the mattress and the size of infestation. If there are holes or tears in the gauze fabric or fabric of the mattress, bed bugs and eggs may be inside, as well as outside. There are restrictions on how beds can be treated with insecticides. We carry both Mattress Safe Bed Bug Encasements and ActiveGuard Mattress Liners.
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Bed bugs occur in all regions of the globe.[7] Rates of infestations are relatively common, following an increase since the 1990s.[3][4][6] The exact causes of this increase is unclear; with proposals including greater travel, more frequent exchange of second-hand furnishings, a greater focus on control of other pests, and increasing resistance to pesticides.[4] Bed bugs have been known human parasites for thousands of years.[2] 

Bed Bugs can re-infest your freshly treated bed, so be sure to stop them from crawling up the bed posts by using Climb-Up Bed Bug Insect Interceptors. The Climb-Up Insect Interceptor is a small dish that is placed under the bed post and captures bedbugs in a a powder coated ring. These type of bed bug traps are very effective and should be used on every bed to help make a complete bed bug proof bed.
The type of reaction provoked depends on previous exposure; repeated bites may lead to an allergic reaction, which may lead to pronounced cutaneous manifestations. Some patients show a severe systemic hypersensitivity to arthropod allergens. The site of the bite can also become secondarily infected with bacteria infection and lead to ecthyma, cellulitis, and/or lymphangitis.
Heat chambers like this one (bottom) can be used to heat personal belongings and kill any hidden bed bugs without chemicals. They come in various sizes, and prices start at less than $200. In the summer, you could let Mother Nature do the dirty work. Bag up your belongings and set them on the driveway. On a day when the temp tops 95 degrees, a bag placed in the sun should easily reach 120 degrees F inside.
Use precautions in your own home. Keep the plastic covering that comes on your mattress when purchased new. Purchase special bedbug covers for you mattress and box spring. Make sure that they are quality ones with heavy duty zippers and constructed with special fabric that doesn't rip easily. Don't buy the cheap versions which are not thick enough to prevent the bedbugs from sticking their feeding tubes into the skin through the cover.[19]
Begin by reducing clutter in the room; things like clothes, books, and other personal belongings shouldn’t be left on the floor, as they make treatment more difficult and add hiding places for bed bugs and eggs. Seal those items in garbage bags and store them away from the room. Any clothing that was picked up or removed from dresser drawers should be dried on high heat for at least 45 minutes. Once treated, clothing that you don’t normally wear should be stored inside garbage bags outside of the infested room.
Bed bugs have a fast and large reproduction nature. On an average, they can reproduce within 200 to 250 eggs at one time, and hatch during an interval between 6 to 10 days. Bed bugs largely live between 4 months to 6 months, and a 1-time treatment is not sufficient to cover the Bed Bug life stages. A 3 times treatment integrated with steam treatment and follow ups across 1.5 to 2 months is usually recommended. Read more here on 6 Questions to Get the Best Treatment for Bed Bugs.
Stripping and vacuuming the mattresses and box springs, and encasing them.  Double bag your bedding and wash in hot water and dry for at least 30 minutes (discard the inner bag after putting bedding into the washer, as it could have bed bugs).  After vacuuming suspected bed bugs from the bed, take your vacuum cleaner outdoors and remove and discard the bag.  Purchase a good quality set of bed-bug-proof encasements for your mattresses and box springs. Bed bug-proof encasements are fabric sacks into which you slide your mattress or your box spring. The zippers on bed bug encasements are designed to be tight enough to prevent even the smallest life stages of the bed bugs from escaping. Also, good bed bug-proof encasements are woven to prevent bed bugs from biting you through the encasement. A good encasement will trap all bed bugs in the mattress and box spring inside, and will be smooth on the outside, providing few places for bed bugs to hide. Sears, Target, Walmart and other stores may sell bed bug-proof encasements, but these can also be purchased online. A good place to look for different brands and reviews of mattress encasements is Amazon.com (whether you buy there or at a local store). Go to http://www.amazon.com and search for “bed bug mattress protectors”.
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