A number of other symptoms may occur from either the bite of the bed bugs or from their exposure. Anaphylaxis from the injection of serum and other nonspecific proteins has been rarely documented.[5][10] Due to each bite taking a tiny amount of blood, chronic or severe infestation may lead to anemia.[5] Bacterial skin infection may occur due to skin break down from scratching.[5][11] Systemic poisoning may occur if the bites are numerous.[12] Exposure to bed bugs may trigger an asthma attack via the effects of airborne allergens although evidence of this association is limited.[5] There is no evidence that bed bugs transmit infectious diseases[5][7] even though they appear physically capable of carrying pathogens and this possibility has been investigated.[5][3] The bite itself may be painful thus resulting in poor sleep and worse work performance.[5]
Bed bug eradication is challenging and it’s prudent to hire a professional when resources allow. However treatment can be expensive, often costing hundreds or thousands of dollars. Those who cannot afford this often must cope with the problem themselves. A useful step that anyone can take to combat bed bugs is to install bed encasements. Covering the mattress and box spring can help eliminate a substantial portion of the bed bug population -- especially if discovered early while most of the bugs are still confined to the bed area. Extra care should be taken when installing budget encasements since these can tear easily, especially on metal bed frames. Ideally both the mattress and box spring should be encased. If only one encasement is possible it’s often best to cover the box spring which is harder to subsequently inspect.
The mechanism of skin injury by arthropods depends on the structure of the mouthparts. These insects are categorized as vessel feeders if they insert the tip into a capillary or as pool feeders if they feed on the extravasated blood from damaged tissue. They often inject different pharmacologically active substances (eg, hyaluronidase, proteases, kinins), which may cause different skin reactions (eg, erythema, wheal, vesicle, hemorrhagic nodule). See the following images.
The exact causes of this resurgence remain unclear; it is variously ascribed to greater foreign travel, increased immigration from the developing world to the developed world, more frequent exchange of second-hand furnishings among homes, a greater focus on control of other pests, resulting in neglect of bed bug countermeasures, and increasing resistance to pesticides.[4][38] Declines in household cockroach populations that have resulted from the use of insecticides effective against this major bed bug predator have aided the bed bugs' resurgence, as have bans on DDT and other potent pesticides.[39][medical citation needed]

To check for signs of a bedbug infestation, Dr. DerSarkissian says that you may notice rusty-colored spots on bed linen and mattresses. These spots could be either blood stains or bedbug excrement. You may also find shed skins around bed frames, mattresses, and other hiding places. Also, a musty smell is usually present where a large number of bed bugs are living.4
Bed bugs are highly vulnerable to heat; exposing them to a certain amount of direct heat will kill them instantly, while lower temperatures can kill them in a matter of minutes. This is why many forms of heat treatments are recommended. Some methods, such as steamers and portable heaters, have been proven effective through professional use and are quickly becoming standard issue in holistic treatment arsenals.

Pull carpet edges back from walls. Being careful, take a pair pliers and gently grab the corners of the carpet and pull the carpet back about 1 foot. Do this one wall at time during treatment. After treatment as described below, replace the carpet and tuck under the baseboards. If you do this 1 wall at time you will not usually need to re-stretch the carpet.

Stripping and vacuuming the mattresses and box springs, and encasing them.  Double bag your bedding and wash in hot water and dry for at least 30 minutes (discard the inner bag after putting bedding into the washer, as it could have bed bugs).  After vacuuming suspected bed bugs from the bed, take your vacuum cleaner outdoors and remove and discard the bag.  Purchase a good quality set of bed-bug-proof encasements for your mattresses and box springs. Bed bug-proof encasements are fabric sacks into which you slide your mattress or your box spring. The zippers on bed bug encasements are designed to be tight enough to prevent even the smallest life stages of the bed bugs from escaping. Also, good bed bug-proof encasements are woven to prevent bed bugs from biting you through the encasement. A good encasement will trap all bed bugs in the mattress and box spring inside, and will be smooth on the outside, providing few places for bed bugs to hide. Sears, Target, Walmart and other stores may sell bed bug-proof encasements, but these can also be purchased online. A good place to look for different brands and reviews of mattress encasements is Amazon.com (whether you buy there or at a local store). Go to http://www.amazon.com and search for “bed bug mattress protectors”.