Bed bugs were mentioned in ancient Greece as early as 400 BC, and were later mentioned by Aristotle. Pliny's Natural History, first published circa AD 77 in Rome, claimed bed bugs had medicinal value in treating ailments such as snake bites and ear infections. (Belief in the medicinal use of bed bugs persisted until at least the 18th century, when Guettard recommended their use in the treatment of hysteria.[51])

Insect bites, including those from the bedbug, have been proposed as a factor contributing to the formation of a cutaneous reaction termed papular urticaria. Patients with papular urticaria have been shown to demonstrate immunoglobulin (Ig) G antibodies to bedbug (C lectularius) antigens. [10] Thus, IgG against C lectularius, Cimex pipiens, and Pulex irritans in patients with papular urticaria may contribute the pathogenesis of this condition.

Begin by reducing clutter in the room; things like clothes, books, and other personal belongings shouldn’t be left on the floor, as they make treatment more difficult and add hiding places for bed bugs and eggs. Seal those items in garbage bags and store them away from the room. Any clothing that was picked up or removed from dresser drawers should be dried on high heat for at least 45 minutes. Once treated, clothing that you don’t normally wear should be stored inside garbage bags outside of the infested room.
Discard affected items. In some cases, infested mattresses and box springs will need to be discarded. Since bed bugs can disperse throughout a building, it also may be necessary to inspect adjoining rooms and apartments. Pay it forward: chop up and/or damage the items you discard so nobody will be tempted to take them home and spread the problem further.[17]
As bed bugs grow they molt, shedding their skin five times before reaching maturity. A blood meal is needed between each successive molt. Adult females also must feed in order to lay eggs. Under favorable conditions (70-80°F), the bugs can mature fully in as little as a month, producing multiple generations per year. Cooler temperatures or limited access to blood prolong the development time. 
Steaming is a great option in rooms and areas where the use of pesticides must be limited due to health or other concerns. When using the steamer, take your time and slowly move the steamer across the item you are treating for the best possible treatment. We still strongly recommend you follow-up with an insecticide labeled for bed bugs in areas where it is permissible to do so. All steaming should be done prior to covering a mattress or box spring with a protective cover and applying insecticides.

While most of the bed bugs were wiped out by the chemicals, three groups continued to thrive after being treated with chlorfenapyr, and five groups were still kicking after being treated with bifenthrin. That means that while some bed bugs will respond to these chemicals, others won't—and it's likely that more and more bugs will become resistant over time.

You can also try spraying an insecticide yourself. Just make sure the product you use is intended to kill bedbugs and is made for the type of space you are using it in (some are intended only for outdoor or garage use, rather than for indoor use in areas where you may be sleeping, cooking, and eating, among other things). And know that insecticides available to professionals are usually stronger and more effective than those that are available to consumers. (6)
First off you should ALWAYS go to pest control if you think you have bedbugs! You shouldn’t try and get rid of them yourself, 99% of the time it does not work. Plus even if you removed infected areas and wash them it wouldn’t kill the eggs. Plus bedbugs are very easy to get but very hard to get rid of. So you should never do it yourself it won’t work!
The bites themselves don't usually pose any major health risk since bedbugs are not known to spread diseases, but an allergic reaction to the bites may require medical attention, CDC officials say. There have also been some strange cases linked to bedbug infestations. Researchers reported in the Canadian Medical Association Journal in 2009 that they treated a 60-year-old man for anemia caused by blood loss from bedbug bites. Another study published in 1991 in the Journal of the Egyptian Society of Parasitology found that people with asthma might be more susceptible to allergic reactions from bedbug bites.

Aerosols (D-Fense NXT, Crossfire Aerosol, or Bedlam Plus) Usage: Simply attach the plastic tip to the aerosol can. Apply as a crack and crevice or spot treatment where evidence of bed bugs occurs. This includes bed frames, box springs, inside empty dressers, clothes closets, curtain rods, hollow spaces, carpet edges, high and low wall moldings and wallpaper edges.
Most people use a combination of bed bug sprays and bed bug powders to kill off bed bugs fast. Bed bugs are notoriously difficult to get rid of and finding the right spray to eliminate bed bugs is not always easy. Many natural residual bed bug sprays contain natural ingredients that have a proven repellent and insecticidal action against these infesting bugs. Some feel that they have to resort to commercial bed bug sprays to completely get rid of an infestation of bed bugs. 

Then it was a baby bed bug. They are super tiny. I hope you washed out your suit case and clothing. I just found her bugs in my home and we think it came from the museum my husband works at where 1000’s of people come day in and day out. Probably transported them from his back pack. It’s been a nightmare for two days now. I’ve had to throw away my curtains and the box spring. It’s just awful. The sprays and foggers are okay but bleach and peppermint oil seems to be working as well as the more expensive remedies.
Track your success. Interceptor cups under your bed posts are also one of the best ways of keeping track of your success with bed bug control. Check the cups regularly and empty into a trash bag or bucket of soapy water.  You may even want to keep track of how many bed bugs you catch weekly so that you can track your success. Wipe out the interceptors and make sure they are clean. Some devices, like the Climbup Interceptor, require redusting with a very small amount of talcum powder to make them slippery again and reduce the bed bug’s chance of escape. Note that talc is not toxic to bed bugs, but simply makes it harder for them to climb out of the cup.  The talc should be barely visible, and more is definitely not better.
Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.
Avoiding bed bugs is most challenging in hotels, apartment buildings, and other places where there are many people, high turnover and ongoing opportunities for introduction of the pests. Periodic, preventive inspection by tenants, housekeeping/maintenance staff, or pest control firms is the best way to detect infestations in their initial stages when they are easiest to control. Visual inspections can be supplemented by using various monitoring devices to capture and reveal bed bugs that may have been overlooked by occupants.   
It takes time and persistence to get rid of bed bugs, and in some cases, the cooperation of landlords, neighbors and others. It can be physically and emotionally exhausting. It can also be expensive when pest control companies are called in. Just remember - bed bugs are more of a nuisance than a health concern and, with vigilance, you can avoid or deal with infestations.
The journal Insects published a study on products containing essential oils for bed bug control. It was found that essential oils like cedar oil, cinnamon oil, clove oil, peppermint oil, rosemary oil, and lemongrass oil all have insecticidal properties against bed bug populations. The study concluded that using these essential oils in a bug spray can be an effective way to reduce bed bug populations without putting humans at risk of exposure to chemicals.8
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