First up are the contact sprays, like STERI-FAB and JT Eaton Kills Bed Bugs. These will kill quickly, but evaporate shortly after, leaving no long-lasting protection. Spray along baseboards, below drawers and on drawer slides, behind cabinets, and behind night stands. Follow up with a residual spray, such as Bedlam Plus and JT Eaton Kills Bed Bugs Plus. Residual sprays will offer long-lasting protection against bed bugs and hatchlings. Bedlam Plus is ideal for cracks and crevices throughout the room, while JT Eaton Plus can be used below the cushions and bases of sofas, chairs, edges of carpets and other fabric items.
Killing all bed bugs on your bed frame and headboard. Normally this would be done by a pest control professional. Approximately 70% of all bed bugs in the typical infestation are located on the mattress, box spring and bed frame.  You’ve encased the mattress and box spring and taken care of that problem.  Now you have to make sure that your bed frame is bed bug free. Vacuuming alone won’t do this.  Vacuuming can remove many bed bug adults and nymphs, but it isn’t very good at removing eggs.  For this job you’ll need insecticide sprays and possibly dusts to treat every crevice and void in your bed.  For insecticide spray and dust options see below. Remember that insecticides can be hazardous if you don’t follow label directions.  Read the whole label before spraying or dusting.  The label directions are the law and failure to follow the label not only puts you and your family at risk, it is against the law.  Homemade sprays, by the way, are usually less safe than commercial insecticides.  Stick with the legal stuff.
Discourage bed bug infestation by keeping clutter picked up, washing bedding and upholstery routinely and not buying used furniture. When you’re traveling, lower your risk of bringing bed bugs back home by opening your suitcase on a hotel desk or luggage rack instead of on the bed; keeping your belongings in your suitcase, not unpacked in dresser drawers; sealing dirty laundry in plastic bags that can be taken straight to the laundry room at home; and inspecting your luggage for bed bug activity before you bring it into your bedroom.
A flashlight:  Bed bugs hide in dark areas and in cracks and crevices.  Bed bugs are a dark red to brown color, but they can be light brown if they haven’t been feeding. This makes it very hard to see them. When hunting for bed bugs hold your flashlight parallel to the surface being inspected, this will cause eggs and small bed bugs to cast a shadow, making them easier to find.
Fumigation using a penetrating gas is another way to de-infest dwellings or furnishings, but the procedure is only offered by certain companies. True fumigation is not the same as setting off a total release fogger or ‘bug bomb.’ (It should be noted that bug bombs are considered ineffective in the treatment of bed bugs, and can be quite dangerous if misused.) The fumigation process is technically complex and requires vacating the building for a period of days. The building is then sealed and injected with a lethal gas, usually sulfuryl fluoride. Because the entire building must be vacated, structural fumigation is logistically more challenging with multi-unit buildings such as apartments, than for single family homes. Bed bug fumigations tend to be more common in southern and western states, where the procedure is also used to control certain types of wood-dwelling termites.  
Once the mattress and box spring are dry, encase them in sealed bed bug encasements. Encasements are crucial, as they prevent bed bugs from entering or escaping the mattress and box spring, cutting off key hiding places. Remember to leave the encasements on for at least 18 months to ensure that any bed bugs already inside have starved to death. Once the encasements have been applied, you can put your mattress and box springs back on your treated bed frame, and put your laundered bedding back on your bed.
Monitor Bed Bug movement with Traps. Bed Bug traps don't work to control bed bugs - they only monitor bed bug movement. Try using Catchmaster 288i Professional Bug Traps by placing them against walls, behind furniture, sticking them under bedframes (yes they work upside down), and anywhere you think bed bugs could be crawling to get back to the bed. Inspect these traps every few days. If you capture bed bugs, then you may have to retreat and do this entire procedure over again. If the traps are empty, then pat yourself on the back for a job well done, but don't think that bed bugs are gone forever. They could be walking around the trap or just waiting for the comforter to hit floor before they climb back into bed!
A few decades ago, bedbugs were somewhat of a novelty in developed countries. But since the early 2000s, infestations have become more common in places like the United States, Canada, the United Kingdom and Europe, according to the U.S. Centers for Disease Control and Prevention (CDC). A 2013 study in the journal Nature Scientific Reports suggested that bedbugs have evolved ways to resist insecticides.

Bedbugs may enter your home undetected through luggage, clothing, used beds and couches, and other items. Their flattened bodies make it possible for them to fit into tiny spaces, about the width of a credit card. Bedbugs do not have nests like ants or bees, but tend to live in groups in hiding places. Their initial hiding places are typically in mattresses, box springs, bed frames, and headboards where they have easy access to people to bite in the night.
DIY bed bug sprays are mostly ineffective in dealing with a large bed bug infestation. This is because a do-it-yourself method lacks proper knowledge on pest behavior to fully control the infestation. For example, bed bugs are real flat and tiny; they hide very well at unexpected places which you may not know. A pest control professional is able to identify key hotspots to treat effectively.
Bedbugs are diagnosed in two ways. The first is the appearance of bites on your body. However, these are very similar to other insect bites and can appear days after being bitten. Finding the signs of bedbugs in your sleeping environment is more conclusive evidence that there is an infestation. You will usually do your own self-diagnosis, but you might see a doctor due to unexplained bite marks or a skin infection after scratching. Learn how to determine whether you have been bitten by bedbugs.
If you need to treat items that can’t be laundered or steamed, you can use a portable bed bug heater, like a ZappBug Oven or a ThermalStrike Ranger. These heaters can safely treat household items like books, papers, CDs, and dry clean only clothing. Not only are bed bug heaters an effective part of a bed bug treatment process, but they’re one of the most popular prevention tools on the market. When you come home from a trip, just put your suitcase in the heater, zip it shut, and turn it on. In just a few hours, any bed bugs or eggs hiding in your belongings will be dead.
You are now ready to inspect other items and put these into the clean zone. As you continue to move things into the clean zone, more of the room will open and you can expand this clean zone. Using this method means you will not have to move furniture and items more than twice. This will allow you to concentrate on searching for bed bugs, rather than moving furniture.
Bring in only what is needed, and avoid sitting or placing coats and other items on beds, floors and sofas where the bugs commonly reside. Essential items can be placed on a tabletop or other hard surface, preferably away from bedrooms and sleeping areas. Better to sit on a hard (non-upholstered) chair than on sofas and recliners. Also try to avoid leaning or brushing against beds and upholstered furniture. If such items are carried out of infested dwellings (e.g., by sanitation workers or firefighters), it’s best to wrap them in plastic or at least not hold them against your body during transport. Emergency Medical (EMS) personnel may need to take additional precautions, such as removing a patient’s bed bug-infested shoes or clothing, or installing plastic sheeting before transporting them in the emergency vehicle.    
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