Insect bites, including those from the bedbug, have been proposed as a factor contributing to the formation of a cutaneous reaction termed papular urticaria. Patients with papular urticaria have been shown to demonstrate immunoglobulin (Ig) G antibodies to bedbug (C lectularius) antigens.  Thus, IgG against C lectularius, Cimex pipiens, and Pulex irritans in patients with papular urticaria may contribute the pathogenesis of this condition.
You can check bedding, mattresses, furniture, and crevices in walls for bed bug infestation. Do your inspection just before dawn, which is when they are the most active. The bugs will be larger and slower after feeding. Bedbugs will quickly flee from light, so live bugs are best located in the folds and seams of mattresses and sheets. Bedbugs are about the size of an apple seed, about 1/4 inch long. They change from light brown to purple-red after feeding. You may also see their eggs, which are about the same size as the adults. The eggs will often be in seams, cracks, or crevices.
Bedbugs are a species of insect known as cimex lectularius (literallycimex is Latin for bug and lactularius is Latin for bed). There is a second common species of bedbugs known as cimex hemiptera. These are known as the tropical bedbugs, staying within 30 degrees of the equator. There are published reports, many without supporting evidence, that each of the common bedbug species has chemically different saliva. Some researchers, however, have found no difference in the reactions caused by each species.
To begin, strip your bed of all sheets, pillowcases, and other bedding, and seal them in plastic garbage bags to keep bed bugs from escaping and infesting other parts of your home. Take the bags straight to the washing machine, and wash them using the hot water setting. Then, dry the bedding on high heat if their tags allow it. This heat treatment will kill any bed bugs or eggs hiding in your bedding.
Wash bedding and clothing (hot water and hot drying cycle for 30–60 minutes), vacuum cracks and crevices, and freeze articles that may have been used as hiding places for bedbugs may reduce infestation until extermination can be performed. Vacuum with special attention to cracks and crevices in furniture, equipment, walls, and floors. Vacuuming some talcum powder will reduce the chance that the bugs will crawl out of the vacuum cleaner. Dispose of the vacuum cleaner filter and bags in a tightly sealed plastic bag.
Inspection requires knowledge, dedication and time. At minimum an inspection should involve a detailed examination of mattresses, box springs and bed frames, as well as likely hiding places for bed bugs within 20 feet of beds and other places where residents may sleep or rest, e.g., on couches). Clutter-free space will be needed to allow furnishings to be moved and manipulated for inspection. In general, rooms with more furnishings will take more time to inspect.
Move your bed away from the wall and put on a bedbug-proof cover, which may be called an encasement or liner. You’ll want to do the same for your box spring if you have one. Unless you have a severe infestation, you may not need to get rid of your mattress. Your exterminator can help you decide if that’s a good option. Either way, it’s important to wait until after treatment is complete to bring a new mattress into your home to avoid it becoming infested, too. (4, 5)
Mix 3 oz per gallon or 0.75 oz per quart and spray with a low pressure sprayer into the areas where the bed bugs are hiding. Typical areas include bed frames, headboards, under beds, baseboards, moldings, behind pictures,etc. Remember to apply in the joints and crevices of furniture. If the crack and crevice is too small, use an aerosol with a crack and crevice tip (recommendations are below.)
That means despite your preventive steps, bed bugs could still get into your house. But of course, that doesn’t translate that taking preventive measures is futile. In contrast, it is a great help in reducing the chance of bed bugs to infest. Nonetheless, it couldn’t completely protect you and your home from the said pests. Hence, you must always be ready to kill bed bugs whenever they get past your defenses.
While encountering bed bugs in hotels is possible, typically only a small number of rooms have problems. If bed bugs are discovered, guests can request another room, preferably in another area of the building, since problems often extend to nearby units. Should you experience itchy welts suggestive of bed bug bites during your stay, it would be prudent upon returning home to place all clothing directly into the washer and/or dryer. Inspecting or vacuuming luggage upon arrival home is less useful since it’s hard to spot bed bugs inside a suitcase. The suitcase itself can either be treated or discarded.