Bed bugs were mentioned in ancient Greece as early as 400 BC, and were later mentioned by Aristotle. Pliny's Natural History, first published circa AD 77 in Rome, claimed bed bugs had medicinal value in treating ailments such as snake bites and ear infections. (Belief in the medicinal use of bed bugs persisted until at least the 18th century, when Guettard recommended their use in the treatment of hysteria.[51])
A common concern with bed bugs is whether or not they transmit diseases. Although bed bugs can harbor various pathogens, transmission to humans has not been proven and is considered unlikely. Their medical significance is most commonly attributed to itching and inflammation from their bites. Antihistamines and corticosteroids may be prescribed to reduce allergic reactions, and antiseptic or antibiotic ointments to prevent infection. Though not known to carry diseases, bed bugs can substantially reduce quality of life by causing discomfort, sleeplessness, anxiety, and embarrassment. According to some health experts, the added stress from living with bed bugs can have a significant impact on the emotional health and well-being of certain individuals. 
Monitor Bed Bug movement with Traps. Bed Bug traps don't work to control bed bugs - they only monitor bed bug movement. Try using Catchmaster 288i Professional Bug Traps by placing them against walls, behind furniture, sticking them under bedframes (yes they work upside down), and anywhere you think bed bugs could be crawling to get back to the bed. Inspect these traps every few days. If you capture bed bugs, then you may have to retreat and do this entire procedure over again. If the traps are empty, then pat yourself on the back for a job well done, but don't think that bed bugs are gone forever. They could be walking around the trap or just waiting for the comforter to hit floor before they climb back into bed!
Other types of bed bug traps include those that do not rely on humans as bait, but instead use CO2and/or other attractants. CO2 is thus far the most powerful lure for bed bugs, as it is the primary cue they follow to locate hosts. Traps that issue CO2 for a period of time are more expensive than Climbup™ traps, but can effectively trap bed bugs when no host is present, such as in common areas, vacant homes or units, offices, schools, and theaters. Thus they can help confirm infestation and eradication.

Stripping and vacuuming the mattresses and box springs, and encasing them.  Double bag your bedding and wash in hot water and dry for at least 30 minutes (discard the inner bag after putting bedding into the washer, as it could have bed bugs).  After vacuuming suspected bed bugs from the bed, take your vacuum cleaner outdoors and remove and discard the bag.  Purchase a good quality set of bed-bug-proof encasements for your mattresses and box springs. Bed bug-proof encasements are fabric sacks into which you slide your mattress or your box spring. The zippers on bed bug encasements are designed to be tight enough to prevent even the smallest life stages of the bed bugs from escaping. Also, good bed bug-proof encasements are woven to prevent bed bugs from biting you through the encasement. A good encasement will trap all bed bugs in the mattress and box spring inside, and will be smooth on the outside, providing few places for bed bugs to hide. Sears, Target, Walmart and other stores may sell bed bug-proof encasements, but these can also be purchased online. A good place to look for different brands and reviews of mattress encasements is Amazon.com (whether you buy there or at a local store). Go to http://www.amazon.com and search for “bed bug mattress protectors”.

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