Bedbug infestations seem to be increasing around the world at an alarming rate, possibly due to insecticide resistance. [1] Resistance to pyrethroid insecticides is already widespread in the United States. The bedbug occurs in aggregations when conditions are favorable, but the arthropods disperse when conditions are unfavorable. [2] Active female dispersal can potentially lead to treatment failures and should be taken into account when using control methods.

Treatment for bedbug bites is typically supportive. Local antiseptic lotions or antibiotic creams can be applied for secondary infections, whereas corticosteroid creams and oral antihistamines can be used for allergic reactions. Bedbugs can be eliminated through the use of permethrin insecticides, baited traps, special bedbug-free beds, and bed nets. Homemade methods, such as wrapping duct tape around bed legs as shown, may be effective, but bedbugs have been known to climb other objects and then fall down onto a bed. Image courtesy of Wikimedia Commons.
We recommend spraying Steri-Fab in areas where live bed bugs are visible. Steri-Fab combines a synthetic pyrethroid insecticide and isopropyl alcohol to kill bed bugs fast on contact. Steri-Fab also acts as a sanitizer. Steri-Fab does not leave any residual, meaning it can be applied virtually anywhere. Simply shake well, then apply to desired treatment areas. Insect mortality is imminent, generally within 10 minutes of spraying.
Bedbugs do, however, have a unique bite pattern. Although some bites may appear alone, most bites occur in a row of three to five bites (termed "breakfast, lunch, and dinner") or in a cluster of red bumps (a rash called bedbug dermatitis). The bites often appear in a zig-zag formation, but may appear in a straight line if the bugs bite you in the morning.
Today, bedbugs can be found in every State in the United States, and almost every city. Bedbugs are so common now that the federal government considers them almost "epidemic". The National Pest Management Association has declared war on bed bugs and has held bedbug meetings all across the Nation to help educate pest control companies in an effort to help control them.
If you think that by discarding the whole bed means getting rid of bed bugs, you are wrong. By moving the mattress and the bed frame, you not only risk moving the bed bugs all around the house, you are also missing out on many other spots these bed bugs could be at. For example, curtains, floor panels and skirting or even the door frames are able to hide these bed bugs very well. The root causes of the infestation must be eradicated fully.
Bed bugs are very hardy insects. Both adults and nymphs can survive prolonged periods without food or under adverse temperature conditions. Adults can live for a year or longer without feeding and can survive over winter in an unheated building. Nymphs are not as hardy as adults, but they can survive for considerable periods under adverse conditions.
When you finish, throw out the vacuum bag to avoid spreading the bugs. If you use a shop vacuum or bagless vacuum, dump the contents you’ve collected into a bag, tie it up, and throw it out. And treat the filter and the inside of the canister with contact spray insecticide. Flat surfaces like walls and dresser tops can be wiped with alcohol. Wipe a small inconspicuous area first to see if the alcohol will damage the paint or finish.
Now that you’ve killed the bed bugs hiding in your bed, it’s time to put up defensive measures to keep them out. Remember, bed bugs can be hiding in all sorts of cracks and crevices throughout your bedroom – in furniture, along baseboards, and inside of the walls – so you need a way to keep them out of your freshly treated bed. By cutting off the infestation’s food supply (you), you halt their breeding and reproductive cycle, making the treatment a whole lot easier.
Treat or isolate your bagged items. For washable items research shows that dry cleaning, washing in hot water for 30 minutes, or tumble drying for 30 minutes on high will kill all stages of bed bugs. Non-washables are a little trickier.  Items that aren’t needed for a while can just be stored. It takes 2-5 months to kill bed bugs by isolating them in bags (the warmer the temperature, the shorter the survival time for starving bed bugs). Heating bags by placing in direct sunlight is one of the most effective methods during the warm summer months.  Seven pounds of items placed in clear bags in direct sunlight on a 95 degree day will get hot enough to kill all bed bug life stages in one afternoon.  Also, placing bagged items in a chest freezer (0 degrees F) for 8-10 hours is lethal for bed bugs and their eggs. Some toys may be disinfested by cleaning with hot soapy water and/or rubbing alcohol.
If the bed bugs are coming from someplace other than your bed, I’d sprinkle uncalcinated diatomaceous earth around cluttered areas and the walls, and bleach the crap out of surrounding furniture. What the diatomaceous earth does is basically attach to their exoskeleton, dehydrate the insect, and they’ll either die of dehydration or get shredded apart as they crawl. Unless your pet or kid would directly eat the diatomaceous earth, it is safe to be in contact with since it’s not a chemical pesticide and it’s fairly cheap.
Bed bugs are attracted to their hosts primarily by carbon dioxide, secondarily by warmth, and also by certain chemicals.[4][16][17][18] Cimex lectularius only feeds every five to seven days, which suggests that it does not spend the majority of its life searching for a host. When a bed bug is starved, it leaves its shelter and searches for a host. It returns to its shelter after successful feeding or if it encounters exposure to light.[19] Cimex lectularius aggregate under all life stages and mating conditions. Bed bugs may choose to aggregate because of predation, resistance to desiccation, and more opportunities to find a mate. Airborne pheromones are responsible for aggregations.[20]

You can make a natural bed bug bite treatment by putting 1 cup distilled water in a spray bottle and adding 10-15 drops tea tree oil. Shake well and spray on areas of skin that have clusters of bed bug bites. Or, you could spray the remedy on a cotton pad and apply to the itchy bumps on your skin. You can also dilutes tea tree oil with a carrier oil, such as coconut oil or sweet almond oil (a few drops of tea tree per one tablespoon of carrier oil).
If you think that by discarding the whole bed means getting rid of bed bugs, you are wrong. By moving the mattress and the bed frame, you not only risk moving the bed bugs all around the house, you are also missing out on many other spots these bed bugs could be at. For example, curtains, floor panels and skirting or even the door frames are able to hide these bed bugs very well. The root causes of the infestation must be eradicated fully.
The Diatomaceous Earth seems to kill them and centipedes. Didn’t even know I had those til I put powder down to prevent bed bugs and found one curled up dead. It dries them out and kills them. Works great! I’ve heard boric acid doesn’t work on bed bugs but I do know it works wonders on killing roaches. My sister had them in an apartment & boric acid wiped them out!
Pay attention to when the bites occur. Consider, for example, if you notice the bites after waking up when previously you hadn't noticed them. However, this can also be difficult to determine because each person's reaction time can vary significantly. Symptoms that result from the bite can manifest at any point from a couple of hours to more than a week after the bite occurred.

^ Kambu, Kabangu; Di Phanzu, N.; Coune, Claude; Wauters, Jean-Noël; Angenot, Luc (1982). "Contribution à l'étude des propriétés insecticides et chimiques d'Eucalyptus saligna du Zaïre (Contribution to the study of insecticide and chemical properties of Eucalyptus saligna from Zaire ( Congo))". Plantes Médicinales et Phytothérapie. 16 (1): 34–38. hdl:2268/14438.
Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.

A flashlight:  Bed bugs hide in dark areas and in cracks and crevices.  Bed bugs are a dark red to brown color, but they can be light brown if they haven’t been feeding. This makes it very hard to see them. When hunting for bed bugs hold your flashlight parallel to the surface being inspected, this will cause eggs and small bed bugs to cast a shadow, making them easier to find.
Checking beds for bed bugs was a common practice long ago, especially while traveling. Travelers today should consider doing the same, preferably before unpacking. This would entail examining the bed sheets and seams of the mattress and perhaps box spring for signs of bed bugs, especially along the head (pillow end) of the bed. Experts also remove and check behind headboards since this is a frequent hiding place for bed bugs in hotels. Headboards are heavy and cumbersome, however, and untrained persons should not attempt removal themselves.

Dust the wall voids. Bed bugs can often travel from room to room, especially in apartments, hotels and condo's. They travel along electrical wiring and plumbing lines. Specifically treat wall voids with a hand duster either by removing wall switch plate covers and/or drill access holes discreetly between studs. Cimexa Dust or Delta Dust are excellent choices for void applications. It kills populations in walls and voids and creates a repellent, hostile environment which reduces the likelihood of bed bugs traveling through voids to other areas. Use a small hand type duster to "puff" insecticidal dusts into these areas. A light coating is all that is needed. To much dust and the bed bugs will just crawl around it.
Alcohol will kill bed bugs but not their eggs and will need to be used often to control infestation. It is not an effective way to get rid of bed bugs permanently. If you want to use this bed bug treatment you need to mix nine parts 91 percent isopropyl (rubbing) alcohol with one part water. Place the solution in a chemical sprayer to cover large areas. Use a spray bottle for small areas and to get into crevices. Spray all areas including head/foot boards, hard surfaces, base boards, door jams and any other bed bug hiding spots.
Some preparation is still required (e.g. removal of heat-sensitive items such as aerosol cans, indoor plants and medications), but it is seldom necessary to bag, launder and/or hot dry bedding and clothing since these items will be heated along with other furnishings. Another advantage of heat treatment is that infestations can often be eliminated in one day, rather than over multiple days or weeks. Conversely, heat treatment alone has no lasting (residual) effect should bed bugs be reintroduced into the dwelling. Consequently, some companies recommend concurrently applying residual insecticides. To further minimize reintroduction, occupants are advised to take as few belongings as possible with them while the heat treatment is in progress.    

It was stated in 2012 that no truly effective insecticides were available.[6] Insecticides that have historically been found effective include pyrethroids, dichlorvos, and malathion.[4] Resistance to pesticides has increased significantly over time, and harm to health from their use is of concern.[3] The carbamate insecticide propoxur is highly toxic to bed bugs, but it has potential toxicity to children exposed to it, and the US Environmental Protection Agency has been reluctant to approve it for indoor use.[33] Boric acid, occasionally applied as a safe indoor insecticide, is not effective against bed bugs[34] because they do not groom.[35]

When professionals need to treat an infestation, they don’t reach for rubbing alcohol or cedar oil or a blow dryer. They use a proven treatment process that involves a combination of proven products to get the job done. It’s not about whether or not a certain item can kill bed bugs, it’s about whether that item is the ideal part of a treatment that will actually get rid of an infestation. After all, your shoe would have a 100% kill rate on any bed bugs you smack with it – that doesn’t mean you can expect to be bed bug free after a diligent afternoon of shoe-wielding.
What’s the best way to get rid of bed bugs? Stop feeding them. To prevent those unwanted dinner guests, isolate your mattress from the rest of the room. Start by pulling the bed away from the wall and away from other furniture like nightstands and chairs. Remove box spring skirting that hangs down to the floor. Oversize blankets that drape to the floor can also act as a ladder for the little buggers.
Unlike those of other insects, bed bug bites may sometimes appear in tight lines of multiple, small, red marks where multiple bed bugs have fed along an exposed area. Bed bug bites can cause itchiness. Initially, a victim may detect a slight burning sensation. The burning area then develops red bumps, known as papules or wheals (rash). In extreme cases, bites may swell dramatically or turn into blister-like skin inflammations.
Some bed bug species are parasites of bats or birds, and may bite people if the wild hosts are no longer available. Although similar in overall appearance, the species of bed bugs that normally feed on bats, swallows, chimney swifts, pigeons or other wild hosts can be differentiated from those that prefer humans. Entomologists and knowledgeable pest managers can make this determination. If bat bugs or bird bugs are present, roosting and nesting sites should be the primary focus, and the animals should be removed and excluded from the building.  
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