Mix 3 oz per gallon or 0.75 oz per quart and spray with a low pressure sprayer into the areas where the bed bugs are hiding. Typical areas include bed frames, headboards, under beds, baseboards, moldings, behind pictures,etc. Remember to apply in the joints and crevices of furniture. If the crack and crevice is too small, use an aerosol with a crack and crevice tip (recommendations are below.)
It was stated in 2012 that no truly effective insecticides were available. Insecticides that have historically been found effective include pyrethroids, dichlorvos, and malathion. Resistance to pesticides has increased significantly over time, and harm to health from their use is of concern. The carbamate insecticide propoxur is highly toxic to bed bugs, but it has potential toxicity to children exposed to it, and the US Environmental Protection Agency has been reluctant to approve it for indoor use. Boric acid, occasionally applied as a safe indoor insecticide, is not effective against bed bugs because they do not groom.
Bed bugs occur around the world. Before the 1950s about 30% of houses in the United States had bedbugs. Rates of infestations in developed countries, while decreasing from the 1930s to the 1980s, have increased dramatically since the 1980s. Before the 1980s they were common in the developing world but rare in the developed world. The increase in the developed world may have been caused by increased international travel, resistance to insecticides, and the use of new pest-control methods that do not affect bed bugs.
To kill bed bugs is to save yourself from a lot of problems. However, before you could eliminate them, there are several preparatory steps that you first have to take so you will know how to get rid of bed bugs. With all those problems and pre-elimination work, many think it is better to prevent the pests by using bed bug spray than to let them in and just get rid of them.
1. Mattress Safe Encasements: Mattress Safe Products are bed encasements to place over your mattress or boxspring so you don't have to throw them away. They are bedbug certified. If using a labeled insecticide on the mattress or boxspring first, apply on mattress or box springs then zip it up. It has a patented hook to keep the bed bugs inside the encasement so they cannot escape. Keep the encasement in place for one year (due to bed bug life cycles).
Bed bugs multiply quickly, and in just six months, a few can turn into a full-on infestation of 13,000 or more. Detection is critical to break the bed bug life cycle before they become a bigger problem. Orkin Bed Bug Detection Service gets to the root of the problem with targeted inspections of common bed bug hiding places in your home and ongoing monitoring to ensure the pests never return.
While your laundry cycle is running, use a vacuum cleaner to remove any bed bugs, shells, fecal droppings, or eggs that might be along the seams of your mattress, pillows, box spring, and along the cracks and crevices in the bed frame, headboard, and footboard. Follow up the vacuuming with a high pressure steamer to penetrate deep inside mattresses, box springs, bed frames, headboards, and footboards to kill bed bugs and eggs on contact.
It’s not likely that you’ll kill all the bed bugs with a bed bug spray. That’s where a residual powder insecticide comes into play. It kills any bugs that wander through the powder. Some powders can kill bugs for many years if left undisturbed. Skip the open areas and spray the powder in those places where you think they’ll be traveling to and from, like near bed legs and under baseboard trim.
At room temperature, bed bugs can survive for up to 3 months without feeding. So, even if no one is living in the room, bed bugs can still survive, especially if there is enough moisture in the air. However, to get rid of bed bugs effectively, you should not just rely on bed bug sprays for exterminating the pests, you should have an integrated pest control management program. This includes using various methods for bed bug removal.
Bed bug eradication is challenging and it’s prudent to hire a professional when resources allow. However treatment can be expensive, often costing hundreds or thousands of dollars. Those who cannot afford this often must cope with the problem themselves. A useful step that anyone can take to combat bed bugs is to install bed encasements. Covering the mattress and box spring can help eliminate a substantial portion of the bed bug population -- especially if discovered early while most of the bugs are still confined to the bed area. Extra care should be taken when installing budget encasements since these can tear easily, especially on metal bed frames. Ideally both the mattress and box spring should be encased. If only one encasement is possible it’s often best to cover the box spring which is harder to subsequently inspect.
Discourage bed bug infestation by keeping clutter picked up, washing bedding and upholstery routinely and not buying used furniture. When you’re traveling, lower your risk of bringing bed bugs back home by opening your suitcase on a hotel desk or luggage rack instead of on the bed; keeping your belongings in your suitcase, not unpacked in dresser drawers; sealing dirty laundry in plastic bags that can be taken straight to the laundry room at home; and inspecting your luggage for bed bug activity before you bring it into your bedroom.
Some people have no reaction whatsoever to bed bugs. In addition to not having much of an effect on the elderly, some are just not allergic. Since the irritation and welting appears as the result of an allergic reaction, it is possible to not even know that you were bitten at all. It is entirely possible for several people to live in the same house, and have one person not be affected.
New tactics may be needed for this escalating public health concern in locations with high occupant turnover, such as hotels, hospitals, and nursing homes.  Indeed, in the past decade bedbugs have become a worldwide urban pest, with the number of American households affected markedly increased.  Genetic data suggest that C lectularius may be undergoing lineage divergence through host association. 
First off you should ALWAYS go to pest control if you think you have bedbugs! You shouldn’t try and get rid of them yourself, 99% of the time it does not work. Plus even if you removed infected areas and wash them it wouldn’t kill the eggs. Plus bedbugs are very easy to get but very hard to get rid of. So you should never do it yourself it won’t work!
Although bedbugs are generally nocturnal, they're like humans—if they're hungry, they'll get up and get something to eat. "If you go away to visit a friend for a week and you come back and sit down on the couch, even though it's daytime the bedbugs will come looking for you," Schal says. Keeping a light on, then, unfortunately does not keep these tiny vampires away.
Dust every crack and crevice. Every crack and crevice, electrical switch plate, wall switch - EVERYTHING - within 10 to 15 feet of the bed should be treated, particularly those closest to the bed. Use the "running method" of moving the application tip along the length of the crack. Look for cracks from the ground level to the ceiling as you treat each section of the room. Use Cimexa Dust or Delta Dust. If you make a mess, simply wipe it up. To much insecticide is better than too little for bed bug control.
Bed bug infestations usually occur around or near the areas where people sleep. These areas include apartments, shelters, rooming houses, hotels, cruise ships, buses, trains, and dorm rooms. They hide during the day in places such as seams of mattresses, box springs, bed frames, headboards, dresser tables, inside cracks or crevices, behind wallpaper, or any other clutter or objects around a bed. Bed bugs have been shown to be able to travel over 100 feet in a night but tend to live within 8 feet of where people sleep.
Systematically examine and treat all furniture (beds, bed frames, dressers, chairs, couches, night stands, etc.) following the same procedures and recommendations above. As a piece is treated it can be returned to the parts of the room that have been treated. Note that furniture should be taken apart, drawers and cushions removed in order to inspect and treat every nook and cranny. When treating upholstered furniture, pay attention to each welt, button and fold. You may wish to discard low-value, stuffed furniture that is infested and too difficult to treat. After spraying, return each article of furniture to the part of the room that has been treated. Do not reintroduce any furniture or other items to the treated room until they have been thoroughly cleaned, inspected or treated.
Once Step 2B is complete and the insecticide mixture is dry, you can follow up with a bed bug aerosol spray. Bed bug aerosol sprays are insecticides that have fine particles that get deep into cracks and crevices. By using both a liquid concentrate insecticide mixture and an aerosol spray, you can treat bed bugs that may have built up a resistance to one product but not the other.