To use sprays effectively to eliminate all traces of bed bugs, you need to know the signs of a bed bug infestation. The first sign that you may have bedbugs are some itchy bite marks on your skin when you wake up in the morning. Dr. Carol DerSarkissian on WebMD says that the bites from bed bugs cause red itchy bumps on the skin.3 You can learn about their other signs and symptoms in my articles on what do bed bug bites look like.
Blood spots found on one's sheets, bites and the presence of bed bug feces and cast skins are some of the indications of a bed bug infestation. Bites are commonly found on the parts of the body that are more likely to be exposed to bed bugs during sleep - the hands, neck, face, shoulders, legs and arms. While not always the case, bed bug bites are often grouped together in a small area and at times may occur in a line or a zigzag pattern. Bites normally look like small, flat or raised areas that may become inflamed, itchy, red or blistered. Bed bug bite reactions don’t always appear immediately after you’re bitten and may take a few days to begin causing symptoms. However, not everyone reacts to bed bug bites in the same manner.
They also have the ability to travel beyond the bedroom, so all adjoining rooms should be checked for infestation. Any area that offers a layer of protection, e.g. dark, isolated areas, should be checked. They do leave excrement droppings behind, so even if they are not seen, you can often see where they have been. The best method to find them is to check only at night, and with a red light.
Pest management professionals are increasingly looking to heat to control bed bugs. Whole houses and, in some cases, multi-unit structures are heated to temperatures well above those lethal to bed bugs, to help assure uniform heating of household contents. Rooms must be heated for several hours during which bulky contents are turned to help ensure heat penetration deep enough to kill bed bugs hiding inside.
As mentioned earlier, applying insect repellent at bedtime will probably not deter bed bugs from biting. When working in severely infested dwellings, there may be some benefit to spraying tops and bottoms of shoes with DEET-based repellents. Those working in bed bug-infested environments may also want to hot wash or run clothing, etc. through a dryer upon returning home or to the office.    
^ Johann Friedrich Wolff; Johann Philip Wolff. "According to Scopoli's 2nd work (loc. cit.), found in Carniola and adjoining regions. According to Linnaeus' second work on exotic insects (loc. cit.), before the era of health, already in Europe, seldom observed in England before 1670". Icones Cimicum descriptionibus illustratae. p. 127. Retrieved 1 December 2016. fourth fascicle (1804)
First up is the most commonly recommended tool by far: rubbing alcohol diluted in water. This is suggested because alcohol can kill bed bugs on contact, and evaporates shortly after, so it’s considered safe for use pretty much anywhere in a home. A recurring theme in these recommendations are household items that are considered to be safer for people than mainstream chemicals.
The size of bed bug bites varies with a number of different factors. Bed bugs inject an anti-coagulant along with their saliva when they pierce the skin to take a blood meal. This anti-coagulant is mostly responsible for how a person reacts to the bite and determines the size of the bug’s bite. Since people will have various sensitivities to the bed bug’s bite, the size of the bite will vary, as well. Another factor that influences the size of a bed bug reaction is the number of times a person is bitten. Bite reactions of people bitten many times are also variable, and their response may be either more or less intense as the number of bites increases.
The decline of bed bug populations in the 20th century is often credited to potent pesticides that had not previously been widely available.[44] Other contributing factors that are less frequently mentioned in news reports are increased public awareness and slum clearance programs that combined pesticide use with steam disinfection, relocation of slum dwellers to new housing, and in some cases also follow-up inspections for several months after relocated tenants moved into their new housing.[66]

To know it's bedbugs, it's important to find the bugs themselves. Look at bedsheets and mattresses for little spots of blood, rusty-looking stains (crushed bugs), or black dots (bugs' poop). You might see live bugs around the seams or tags of mattresses and box springs, or in cracks of bed frames and other furniture. They can even hide in books, carpet edges, and electrical outlets.
Then it was a baby bed bug. They are super tiny. I hope you washed out your suit case and clothing. I just found her bugs in my home and we think it came from the museum my husband works at where 1000’s of people come day in and day out. Probably transported them from his back pack. It’s been a nightmare for two days now. I’ve had to throw away my curtains and the box spring. It’s just awful. The sprays and foggers are okay but bleach and peppermint oil seems to be working as well as the more expensive remedies.
Quote: Similarly, bed bugs will perish in extremely cold temperatures. If it is possible to keep a room unheated for a prolonged period of time, it may kill the population. All stages of the common bed bug, from nymphs to adults, can survive for up to five days in temperatures of fourteen degrees Fahrenheit. Prolonged exposure, however, to these temperatures, will kill them.
Bed bugs were first mentioned in Germany in the 11th century, in France in the 13th century, and in England in 1583,[50] though they remained rare in England until 1670. Some in the 18th century believed bed bugs had been brought to London with supplies of wood to rebuild the city after the Great Fire of London (1666). Giovanni Antonio Scopoli noted their presence in Carniola (roughly equivalent to present-day Slovenia) in the 18th century.[52][53]
When bed bugs are suspected, sleeping and resting places should be thoroughly inspected. Check all possible hiding places, mindful that bed bugs, especially the young nymphs and eggs, can fit into very tiny cracks and crevices. Don’t overlook places where pets rest, and where bats or birds have entered structures. In these instances, bat or bird bugs, not bed bugs, may be present. If bats or birds are a source of infestation, they should be excluded from the premises. Note that bats and most bird species are protected by law and should not be killed. Contact the Illinois Department of Natural Resources for guidelines on bat or bird exclusion and removal.
To begin, strip your bed of all sheets, pillowcases, and other bedding, and seal them in plastic garbage bags to keep bed bugs from escaping and infesting other parts of your home. Take the bags straight to the washing machine, and wash them using the hot water setting. Then, dry the bedding on high heat if their tags allow it. This heat treatment will kill any bed bugs or eggs hiding in your bedding.
^ John Southall. "That soon after the Fire of London, in some of the new-built Houses they were observ'd to appear, and were never noted to have been seen in the old, tho' they were then so few, as to be little taken notice of; yet as they were only seen in Firr-Timber, 'twas conjectured they were then first brought to England in them; of which most of the new Houses were partly built, instead of the good Oak destroy'd in the old". A Treatise of Buggs [sic], pp. 16–17. Retrieved 1 December 2016.
It is also recommended to put infested items, such as a mattress, in a sauna that reaches temperatures of upwards of 170° Fahrenheit. Similarly, they also perish in extremely cold temperatures so mattresses and other items can be cleansed of these bugs with the use of plastic wrap and dry ice. Cover the items with large plastic tarps and carefully insert dry ice, and then secure. The extreme temperature will naturally fumigate the pests.
Bedbugs live in any articles of furniture, clothing, or bedding, so they or their eggs may be present in used furniture or clothing. They spread by crawling and may contaminate multiple rooms in a home or even multiple dwellings in apartment buildings. They may also hide in boxes, suitcases, or other items that are moved from residence to residence or from a hotel to home. Bedbugs can live on clothing from home infestations and may be spread by a person unknowingly wearing infested clothing.
Traditional methods of repelling and/or killing bed bugs include the use of plants, fungi, and insects (or their extracts), such as black pepper;[54] black cohosh (Actaea racemosa); Pseudarthria hookeri; Laggera alata (Chinese yángmáo cǎo | 羊毛草);[15] Eucalyptus saligna oil;[55][56] henna (Lawsonia inermis or camphire);[57] "infused oil of Melolontha vulgaris" (presumably cockchafer); fly agaric (Amanita muscaria); tobacco; "heated oil of Terebinthina" (i.e. true turpentine); wild mint (Mentha arvensis); narrow-leaved pepperwort (Lepidium ruderale); Myrica spp. (e.g. bayberry); Robert geranium (Geranium robertianum); bugbane (Cimicifuga spp.); "herb and seeds of Cannabis"; "opulus" berries (possibly maple or European cranberrybush); masked hunter bugs (Reduvius personatus), "and many others".[58]

While most of the bed bugs were wiped out by the chemicals, three groups continued to thrive after being treated with chlorfenapyr, and five groups were still kicking after being treated with bifenthrin. That means that while some bed bugs will respond to these chemicals, others won't—and it's likely that more and more bugs will become resistant over time.

Bed bugs are active mainly at night. During the daytime, they prefer to hide close to where people sleep. Their flattened bodies enable them to fit into tiny crevices--especially those associated with mattresses, box springs, bed frames and headboards. Bed bugs do not have nests like ants or bees, but do tend to congregate in habitual hiding places. Characteristically, these areas are marked by dark spotting and staining, which is the dried excrement of the bugs. Also present will be hatched and un-hatched eggs, the tannish shed skins of maturing nymphs, and the bugs themselves. Another possible sign are rusty or reddish smears on bed sheets or mattresses from crushed engorged bed bugs. Although it’s often stated that bed bugs have a telltale “buggy” odor, the smell is seldom evident except in extreme infestations and should not be relied upon for detection.
Ticks are known transmitters of disease to humans and animals. Tick-borne diseases include Lyme disease, Rocky Mountain spotted fever, Q fever, tularemia, babesiosis, and Southern tick-associated rash illness. Infected ticks spread disease once they've bitten a host, allowing the pathogens in their saliva and mouth get into the host's skin and blood. Tick bites are typically painless, but the site of the bite may later itch, burn, turn red, and feel painful. Individuals allergic to tick bites may develop a rash, swelling, shortness of breath, numbness, or paralysis. Tick bite treatment involves cleaning and applying antibiotic cream.
To use EcoRaider, the manufacturers recommend spraying all edges and seams of mattresses, as well as box springs, and bed frames. You can also use the spray to kill bed bugs from cushions, behind baseboards, edges of carpets, and moldings. It is safe for the whole household and won’t harm pets. You can get more information about EcoRaider and purchase it in Amazon here.
Wash all linen on hot, dry on hot setting. Gather all linen, cloth and leather bags, mattress covers, clothing, teddy bears... etc. Machine wash on hot - wash the laundry bag also. Tumble dry on hot. Steam kills bed bugs. Some metropolitan areas offer bed bug laundry and dry cleaning services which have the added benefits of proven methods for killing bed bugs and bagging or storing cleaned items so they do not become re-infested while the home is still being exterminated.

Many news reports in recent years have focused on the discovery of bedbugs and their health effects (even in upscale five-star hotels), and a number of lawsuits have been filed by guests of fashionable hotels who awoke to find hundreds of bedbug bites covering their skin. Searching on travel-review web sites regularly reveals information and even photos confirming the presence of bedbugs in numerous hotels.
As bed bugs grow they molt, shedding their skin five times before reaching maturity. A blood meal is needed between each successive molt. Adult females also must feed in order to lay eggs. Under favorable conditions (70-80°F), the bugs can mature fully in as little as a month, producing multiple generations per year. Cooler temperatures or limited access to blood prolong the development time. 
My husband works for a garbage company (this is how we think the invasion started) and at the moment they are localized to our bedroom and our bathroom. However, the first place we found them was in our headboard & footboard. It is wood with an intricate carving. We checked the mattress and box spring and didn’t find a thing. But they LOVE that wood.
Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.
Once the mattress and box spring are dry, encase them in sealed bed bug encasements. Encasements are crucial, as they prevent bed bugs from entering or escaping the mattress and box spring, cutting off key hiding places. Remember to leave the encasements on for at least 18 months to ensure that any bed bugs already inside have starved to death. Once the encasements have been applied, you can put your mattress and box springs back on your treated bed frame, and put your laundered bedding back on your bed.
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