Consider using insecticides. Residual insecticides (usually pyrethroids) are applied as spot treatments to cracks and crevices where bed bugs are hiding. Increased penetration of the insecticide into cracks and crevices can be achieved if accumulated dirt and debris are first removed using a vacuum cleaner. Many readily available aerosol pesticide sprays will cause bed bugs to scatter making eradication more difficult. Dust formulations may be used to treat wall voids and attics.[16]
Alternatively, place a bed bug proof mattress cover over an infested mattress to trap the bed bugs inside and starve them to death. This will eliminate the need to purchase a new mattress/boxspring and make treatment and future inspections easier. (Starving the bugs CAN take up to 400 days, so make sure your cover stays sealed for at least that long.)[6]
Research has shown that some bed bugs are resistant to the pyrethroid pesticides that have been most commonly used in recent years by pest management professionals. Likewise, pyrethroids such as deltamethrin and permethrin have been among the active ingredients most commonly available in pesticides at retail stores. The ongoing use of pyrethroids has undoubtedly contributed to the resistance we see today in some bed bug populations.
The decline of bed bug populations in the 20th century is often credited to potent pesticides that had not previously been widely available.[44] Other contributing factors that are less frequently mentioned in news reports are increased public awareness and slum clearance programs that combined pesticide use with steam disinfection, relocation of slum dwellers to new housing, and in some cases also follow-up inspections for several months after relocated tenants moved into their new housing.[66]
Some pest control firms also employ commercial steamers or spot-freezing equipment to treat areas where bed bugs are found or suspected. Used correctly, they kill bugs and eggs on contact. Neither method, however, affords residual protection against bed bugs which may have been missed. Steaming and spot-freezing equipment also have limited ability to penetrate fabric, wood, and other materials where bed bugs often reside. 
Itchy swollen bites may be the first sign of a bed bug problem. However, these itchy bites can take as long as 14 days to develop in some people, so it's important to look for other clues if you are concerned about an infestation. Bed bugs typically infest mattresses, box springs, bed frames, and couches. You may be able to find them hiding within the cracks and crevices of beds, furniture, floors, and walls. Bed bugs often leave evidence of small dark stains (fecal droppings) and rusty red spots (bloodstains) on bedding sheets, mattresses, and other areas they hide in or travel along. Heavy bed bug infestations can cause a sweet, musty smell.
Individual responses to bites vary, ranging from no visible effect (in about 20–70%),[5][3] to small macular spots, to prominent wheals and bullae formations along with intense itching that may last several days.[5] The bites often occur in a line. A central spot of bleeding may also occur due to the release of anticoagulants in the bug's saliva.[4]
Specks of blood on bedding, mattresses, or upholstered furniture such as couches and headboards: Look carefully at your blankets, sheets, and mattress pads and then check the mattress and box spring. Are there specks of blood anywhere, especially near the seams? If so, there could be a bed bug infestation. You should also check for specks of blood on all upholstered furniture, including couches and headboards.
A flashlight:  Bed bugs hide in dark areas and in cracks and crevices.  Bed bugs are a dark red to brown color, but they can be light brown if they haven’t been feeding. This makes it very hard to see them. When hunting for bed bugs hold your flashlight parallel to the surface being inspected, this will cause eggs and small bed bugs to cast a shadow, making them easier to find.
Bed bugs can exist singly, but tend to congregate once established. Although strictly parasitic, they spend only a tiny fraction of their lifecycles physically attached to hosts. Once a bed bug finishes feeding, it relocates to a place close to a known host, commonly in or near beds or couches in clusters of adults, juveniles, and eggs—which entomologists call harborage areas or simply harborages to which the insect returns after future feedings by following chemical trails. These places can vary greatly in format, including luggage, inside of vehicles, within furniture, among bedside clutter—even inside electrical sockets and nearby laptop computers. Bed bugs may also nest near animals that have nested within a dwelling, such as bats, birds,[22] or rodents. They are also capable of surviving on domestic cats and dogs, though humans are the preferred host of C. lectularius.[25]

If you suspect that bed bugs might be hiding in items that can’t be laundered or steamed, like books, papers, luggage, shoes, and dry-clean only clothing, you can treat those with a portable bed bug heater. Heaters are a popular way to safely heat-treat items during bed bug treatments, or as a preventative tool for travelers who want to ensure that bed bugs can’t escape from their luggage to infest their home.
Bedbugs are a species of insect known as cimex lectularius (literallycimex is Latin for bug and lactularius is Latin for bed). There is a second common species of bedbugs known as cimex hemiptera. These are known as the tropical bedbugs, staying within 30 degrees of the equator. There are published reports, many without supporting evidence, that each of the common bedbug species has chemically different saliva. Some researchers, however, have found no difference in the reactions caused by each species.

Vacuum your house. This will remove bugs and eggs from mattresses, carpet, walls and other surfaces. Pay particular attention to seams, tufts and edges of mattresses and box springs, and the perimeter edge of wall-to-wall carpets. Afterward, dispose of the vacuum contents in a sealed trash bag. Steam cleaning of carpets is also helpful for killing bugs and eggs that vacuuming may have missed.[14]
Stripping and vacuuming the mattresses and box springs, and encasing them.  Double bag your bedding and wash in hot water and dry for at least 30 minutes (discard the inner bag after putting bedding into the washer, as it could have bed bugs).  After vacuuming suspected bed bugs from the bed, take your vacuum cleaner outdoors and remove and discard the bag.  Purchase a good quality set of bed-bug-proof encasements for your mattresses and box springs. Bed bug-proof encasements are fabric sacks into which you slide your mattress or your box spring. The zippers on bed bug encasements are designed to be tight enough to prevent even the smallest life stages of the bed bugs from escaping. Also, good bed bug-proof encasements are woven to prevent bed bugs from biting you through the encasement. A good encasement will trap all bed bugs in the mattress and box spring inside, and will be smooth on the outside, providing few places for bed bugs to hide. Sears, Target, Walmart and other stores may sell bed bug-proof encasements, but these can also be purchased online. A good place to look for different brands and reviews of mattress encasements is Amazon.com (whether you buy there or at a local store). Go to http://www.amazon.com and search for “bed bug mattress protectors”.
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