Dessicants are substances that destroy the bugs’ protective outer coating. Without this coating, the bugs dry out and die. Two examples of dessicants are silica aerogel (Tri-Die and CimeXa) and diatomaceous earth. The advantage to dessicants is that bedbugs can’t become resistant to them, but they work slowly. These products can take a few months to kill off all the bugs.
Nightstands and dressers may need to be emptied and examined inside and out, and tipped over to inspect the woodwork underneath. Oftentimes the bugs will be hiding in cracks, corners, and recesses. Other common bed bug hiding places include: along and under the edge of wall-to-wall carpeting, especially behind beds and sofas; cracks in wood molding; ceiling-wall junctures; behind wall-mounted pictures, mirrors, outlets and switch plates; under loose wallpaper; clothing and clutter within closets; and inside clocks, phones, televisions and smoke detectors.
Bed bugs were first mentioned in Germany in the 11th century, in France in the 13th century, and in England in 1583,[50] though they remained rare in England until 1670. Some in the 18th century believed bed bugs had been brought to London with supplies of wood to rebuild the city after the Great Fire of London (1666). Giovanni Antonio Scopoli noted their presence in Carniola (roughly equivalent to present-day Slovenia) in the 18th century.[52][53]
The mechanism of skin injury by arthropods depends on the structure of the mouthparts. These insects are categorized as vessel feeders if they insert the tip into a capillary or as pool feeders if they feed on the extravasated blood from damaged tissue. They often inject different pharmacologically active substances (eg, hyaluronidase, proteases, kinins), which may cause different skin reactions (eg, erythema, wheal, vesicle, hemorrhagic nodule). See the following images. 

Bed bugs are highly vulnerable to heat; exposing them to a certain amount of direct heat will kill them instantly, while lower temperatures can kill them in a matter of minutes. This is why many forms of heat treatments are recommended. Some methods, such as steamers and portable heaters, have been proven effective through professional use and are quickly becoming standard issue in holistic treatment arsenals.

Reactions to bed bug bites vary among individuals. Many persons show no signs of bites. Others don’t realize they’ve been bitten until redness and swelling appear around the bite, sometimes with intense itching. Some exhibit inflamed swollen spots that may occur in linear series or have a rash-like appearance. Such bite marks, when they appear, may not show for several days after the person is bitten.
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