Reactions to bed bug bites vary among individuals. Many persons show no signs of bites. Others don’t realize they’ve been bitten until redness and swelling appear around the bite, sometimes with intense itching. Some exhibit inflamed swollen spots that may occur in linear series or have a rash-like appearance. Such bite marks, when they appear, may not show for several days after the person is bitten.
Alternatively, place a bed bug proof mattress cover over an infested mattress to trap the bed bugs inside and starve them to death. This will eliminate the need to purchase a new mattress/boxspring and make treatment and future inspections easier. (Starving the bugs CAN take up to 400 days, so make sure your cover stays sealed for at least that long.)[6]

The best bed bug traps are those that are used under the bed. The Climb-Up Bed Bug Interceptor is placed below the bed frame rollers or legs. The Climb-Up prevents bed bugs from being able to crawl either from the bed to the floor or from the floor to the bed. The Climb-Up works very well at isolating the bed from the floor and making it bed bug proof. As long as the comforter or some other linen is not touching the floor, then the bed is protected.
Because their bodies are flat, they can hide under the smallest spots like the border of beds, under the mattress, edges of carpets, couches, cracks in the walls and ceilings, in your pillows, under your bed sheets, behind electrical plugs and wall sockets, in your cupboards and dressers, or under furniture. In fact, bed bugs prefer any fabric materials. They can travel pretty good distances, too. Expect them to be able to be found anywhere in the room.

Bedbugs lurk in cracks and crevices and they've been living on human blood for centuries. Though they aren't known to transmit disease or pose any serious medical risk, the stubborn parasites can leave itchy and unsightly bites. However, bedbugs don't always leave marks. The best way to tell if you have a bedbug infestation is to see the live, apple-seed-size critters for yourself. Unfortunately, once bedbugs take up residence in homes and businesses, they can be difficult to exterminate without professional help.
Bed bug eradication is challenging and it’s prudent to hire a professional when resources allow. However treatment can be expensive, often costing hundreds or thousands of dollars. Those who cannot afford this often must cope with the problem themselves. A useful step that anyone can take to combat bed bugs is to install bed encasements. Covering the mattress and box spring can help eliminate a substantial portion of the bed bug population -- especially if discovered early while most of the bugs are still confined to the bed area. Extra care should be taken when installing budget encasements since these can tear easily, especially on metal bed frames. Ideally both the mattress and box spring should be encased. If only one encasement is possible it’s often best to cover the box spring which is harder to subsequently inspect.
If you need to treat items that can’t be laundered or steamed, you can use a portable bed bug heater, like a ZappBug Oven or a ThermalStrike Ranger. These heaters can safely treat household items like books, papers, CDs, and dry clean only clothing. Not only are bed bug heaters an effective part of a bed bug treatment process, but they’re one of the most popular prevention tools on the market. When you come home from a trip, just put your suitcase in the heater, zip it shut, and turn it on. In just a few hours, any bed bugs or eggs hiding in your belongings will be dead. 

Cracks and crevices of bed frames should also be examined, especially if the frame is wood. (Bed bugs have an affinity for wood and fabric more so than metal or plastic.) Wooden support slats, if present, should be removed and examined since bed bugs often congregate where the ends rest on the frame. Screw holes, knots and other recesses are also common hiding places. Headboards secured to walls should be removed and inspected. In hotels, the area behind the headboard is often the first place that bed bugs become established. Bed bugs also frequently hide within items stored under beds. 
Treat other areas in your home.  This is perhaps the most challenging part of do-it-yourself bed bug control.  If you catch an infestation early you may not need to do anything more than treat and isolate your bed as described above.  But if an infestation has spread to other parts of the home, bed isolation may not be good enough. Here is where professional help may be needed, especially if you’re not up to moving furniture. Still determined?  Here are some tips that may improve your chances of success:
However, low-level infestations are also much more challenging to find and correctly identify. Other insects, such as carpet beetles, can be easily mistaken for bed bugs. If you misidentify a bed bug infestation, it gives the bugs more time to spread to other areas of the house or hitchhike a ride to someone else's house to start a new infestation. Learn about identifying bed bugs.
Application entails treating all areas where the bugs are found or tend to hide or crawl. This takes considerable effort and follow-ups are usually needed. Companies typically treat seams, folds and crevices of bed components, chairs and sofas, but usually will not spray the entire sleeping surface or seating area. They also do not spray bed sheets, blankets or clothing, which instead should be hot washed or heated in a dryer. 
Isolating your bed from the rest of the house.  If you don’t use a bed, purchase a frame that gets your mattress off the floor and install bed bug interceptors under all feet of the bed frame to keep bed bugs off your bed while you are sleeping. Interceptors are special platforms or cups that are purchased to prevent bed bugs from climbing on to your bed.  An interceptor can be as simple as a sticky card placed under a bed post (sticky and messy).  Better are one of the commercial pitfall traps made specifically for this purpose.  The Climbup™ Bed bug Interceptor and BlackOut BedBug Detector (Google them) are two such products sold online. Relatively inexpensive, these cups trap bed bugs attempting to climb (or exit) the bed. If you have encased your bedding, treated your bed frame thoroughly and installed interceptors, you will be instantly protected against bed bugs.  Don’t take out your clean bedding or put it back on the bed until the bed has been treated (and dried) and encasements installed. And note that for this method to be effective, beds and bedding must not touch the floor, furniture or walls.  This would provide bed bugs other ways to climb onto the bed and foil your defenses.
Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.
Many news reports in recent years have focused on the discovery of bedbugs and their health effects (even in upscale five-star hotels), and a number of lawsuits have been filed by guests of fashionable hotels who awoke to find hundreds of bedbug bites covering their skin. Searching on travel-review web sites regularly reveals information and even photos confirming the presence of bedbugs in numerous hotels.
Bed bugs are experts at hiding. Their slim flat bodies allow them to fit into the smallest of spaces and stay there for long periods of time, even without a blood meal. Bed bugs are usually transported from place to place as people travel. The bed bugs travel in the seams and folds of luggage, overnight bags, folded clothes, bedding, furniture, and anywhere else where they can hide. Most people do not realize they are transporting stow-away bed bugs as they travel from location to location, infecting areas as they travel.
Alcohol will kill bed bugs but not their eggs and will need to be used often to control infestation. It is not an effective way to get rid of bed bugs permanently. If you want to use this bed bug treatment you need to mix nine parts 91 percent isopropyl (rubbing) alcohol with one part water. Place the solution in a chemical sprayer to cover large areas. Use a spray bottle for small areas and to get into crevices. Spray all areas including head/foot boards, hard surfaces, base boards, door jams and any other bed bug hiding spots.
* Typically used for control of wood-destroying organisms, true fumigation of structures is occasionally performed for bed bug control. Fumigating a structure involves “tenting” it, i.e., draping and sealing it with tarps so that the fumigant, a poisonous gas, can be applied into and contained within the structure where it penetrates the contents and kills all pests within. Like whole-room heat treatments, fumigation has no lasting effect (it leaves no pesticide residue), is labor-intensive, and can damage contents. It is also more expensive, especially in northern states where fumigations are done less frequently. The advantage of fumigation over heat treatment may be that fumigation is more likely to kill all the pests within a structure.
Bedbugs are small, flat, wingless insects with six legs that, like mosquitoes, feed on blood from animals or people. They range in color from almost white to brown, but they turn rusty red after feeding. The common bedbug doesn't grow much longer than 0.2 inches (0.5 centimeters) and can be seen by the naked eye to the astute observer.  Bedbugs get their name because they like to hide in bedding and mattresses.
"By every metric that we use, it's getting worse and worse," says Coby Schal, an entomologist at North Carolina State University in Raleigh. Health authorities and pest control operators are regularly flooded with calls, and the epidemic may not have yet peaked. And because bedbugs are indoor pests, there are no high or low seasons throughout the year, he adds, only continual bombardment. "It's just the beginning of the problem in the U.S.," Schal says.
In the case of beds, a more economical option is to encase both the mattress and box spring in a protective cover like those used for allergy relief. Encasements specifically designed to help protect against bed bugs are available through retail or pest control firms. Higher quality ones tend to be more durable and comfortable to sleep on. Once the encasement is installed and zipped shut, any bugs which happen to be inside are entombed and eventually will die. Encasements also help protect newly purchased beds, and make it easier to spot and destroy any bugs residing on the outer surface during subsequent examination. Encasements will not, however, keep bed bugs from crawling onto a bed and biting a sleeping person.
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