Mix an insecticide labeled for use on bed bugs, such as Temprid FX, with water in a pump sprayer using the ratio found on the product label to create a bed bug spray. Spray onto baseboards, in corners, around door and window frames, around bed frames, and under furniture. Do not broadcast spray an entire carpet or floor. Allow the spray to dry before moving on to the next step.
Vigilant travelers may also want to elevate suitcases off the floor on a stand, tabletop or other hard surface rather than storing them on the floor or another bed. Hyper-vigilant travelers may further opt to keep belongings in sealed plastic pouches and their suitcase in a zippered tote — however each traveler must decide how cautious they wish to be. 
Traditional methods of repelling and/or killing bed bugs include the use of plants, fungi, and insects (or their extracts), such as black pepper;[54] black cohosh (Actaea racemosa); Pseudarthria hookeri; Laggera alata (Chinese yángmáo cǎo | 羊毛草);[15] Eucalyptus saligna oil;[55][56] henna (Lawsonia inermis or camphire);[57] "infused oil of Melolontha vulgaris" (presumably cockchafer); fly agaric (Amanita muscaria); tobacco; "heated oil of Terebinthina" (i.e. true turpentine); wild mint (Mentha arvensis); narrow-leaved pepperwort (Lepidium ruderale); Myrica spp. (e.g. bayberry); Robert geranium (Geranium robertianum); bugbane (Cimicifuga spp.); "herb and seeds of Cannabis"; "opulus" berries (possibly maple or European cranberrybush); masked hunter bugs (Reduvius personatus), "and many others".[58]
To use sprays effectively to eliminate all traces of bed bugs, you need to know the signs of a bed bug infestation. The first sign that you may have bedbugs are some itchy bite marks on your skin when you wake up in the morning. Dr. Carol DerSarkissian on WebMD says that the bites from bed bugs cause red itchy bumps on the skin.3 You can learn about their other signs and symptoms in my articles on what do bed bug bites look like.
While the mattress and box spring are left to dry, spray down the joints of the bed frame, headboard, and footboard with a contact spray and residual spray. The contact spray will kill bed bugs quickly and then evaporate, while the residual spray will kill bed bugs over several weeks. Remember to follow the sprays’ product labels and MSDS for safe and effective usage.
Mechanical approaches, such as vacuuming up the insects and heat-treating or wrapping mattresses, are effective.[3][6] An hour at a temperature of 45 °C (113 °F) or over, or two hours at less than −17 °C (1 °F) kills them.[6] This may include a domestic clothes drier for fabric or a commercial steamer. Bed bugs and their eggs will die on contact when exposed to surface temperatures above 180 °F (82 °C) and a steamer can reach well above 230 °F (110 °C).[31][15] A study found 100% mortality rates for bed bugs exposed to temperatures greater than 50 °C (122 °F) for more than 2 minutes. The study recommended maintaining temperatures of above 48 °C (118 °F) for more than 20 min to effectively kill all life stages of bed bugs, and because in practice treatment times of 6 to 8 hours are used to account for cracks and indoor clutter.[32] This method is expensive and has caused fires.[6][15] Starving them is not effective as they can survive without eating for 100 to 300 days, depending on temperature.[6] One expert recommends not trying to get rid of bed bugs exclusively on one's own.[29]

Bedbugs normally feed at night, usually approximately 1 hour before dawn. However, if the conditions are favorable, they also feed during the day. Feeding takes 3-12 minutes. In proper conditions, adult bedbugs can survive without a meal for 1 year or longer. Each female lays approximately 300 eggs in her lifetime. The eggs hatch in 10 days. The nymph stage lasts 6 weeks, undergoing 5 molts.
Unfortunately standard insect monitors (“sticky traps”) are not very good at trapping bed bugs. To date, the best bed bug trap as measured by cost, ease of use, and effectiveness, is the “Climbup™ Insect Interceptor.” This trap resembles a plastic dish and is placed beneath the legs of beds and other furniture on which persons might relax and serve as “bait” for bed bugs. Bed bugs that climb into the dish are unable to climb its slippery inner surface (which is coated with talcum powder). Studies have shown that even inspections performed by trained and experienced pest management professionals often miss some bed bugs, especially in heavier infestations, and that bed leg traps can catch many of those missed bed bugs.
Low toxicity contact sprays like SteriFab™ or Bedlam® are likely to kill bed bugs only on contact. Alcohol- and soap-based sprays, are only partly effective. All of these products, once dry, are likely to provide no further control. Eggs will not be killed by alcohol-based sprays, so repeat treatments are usually needed. Be careful when using sprays containing alcohol because they may be flammable.
Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.
Apply as a coarse, low-pressure spray to harborage areas including crevices, baseboards, loose plaster, behind bed frames and headboards, beneath beds and furniture, and to bedsprings and bed frames. After removal of bed linens, apply Transport Mikron to mattress and boxsprings. Apply to tufts, edges, seams and folds (do not spray clothes or bed linens). Your may apply it to furniture, but not to areas where there is direct access to seating or arm placements. Infested bed linens should not be treated, but should be removed, placed in sealed plastic bags, and taken for laundering and drying at high temperatures.
Bedbugs are highly resistant to many sprays. There are, however, certain sprays that may be able to kill bedbugs. Check with a professional exterminator about advice using sprays to try and remove the bedbugs yourself. Dead bedbugs usually won't move, may be arched back, or red in color. Ultimately, you may be better off replacing your mattress and bedding and fumigating your home to kill the bedbugs.
Bedbugs are parasitic arthropods from the family Cimicidae. They are typically less than 1 cm in length and reddish brown in color. Bedbugs can be found in furniture, floorboards, peeling paint, or other small spaces, most commonly in areas of clutter. These insects come out at night in search of prey upon which to feed, with peak feeding times just before dawn. Bedbugs are typically attracted to body heat, carbon dioxide, vibration, sweat, and odor. The image of a Cimex lectularius is shown courtesy of the US Centers for Disease Control and Prevention (CDC).
The decline of bed bug populations in the 20th century is often credited to potent pesticides that had not previously been widely available.[44] Other contributing factors that are less frequently mentioned in news reports are increased public awareness and slum clearance programs that combined pesticide use with steam disinfection, relocation of slum dwellers to new housing, and in some cases also follow-up inspections for several months after relocated tenants moved into their new housing.[66]

Consider using insecticides. Residual insecticides (usually pyrethroids) are applied as spot treatments to cracks and crevices where bed bugs are hiding. Increased penetration of the insecticide into cracks and crevices can be achieved if accumulated dirt and debris are first removed using a vacuum cleaner. Many readily available aerosol pesticide sprays will cause bed bugs to scatter making eradication more difficult. Dust formulations may be used to treat wall voids and attics.[16]
Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.

Great read and very helpful info. However, when you describe how to use essential oil sprays for bed bug treatment, it would be most helpful if you included the amount of water used to mix with the oils. Simply stating to use “a small spray bottle filled with water” isn’t a very good description. A quick search for “small spray bottle” will get results for a wide range from 2-ml to 16-ounce bottles, all classified as small. This makes for a rather potent mixture to an extremely weak mixture.
Dust the wall voids. Bed bugs can often travel from room to room, especially in apartments, hotels and condo's. They travel along electrical wiring and plumbing lines. Specifically treat wall voids with a hand duster either by removing wall switch plate covers and/or drill access holes discreetly between studs. Cimexa Dust or Delta Dust are excellent choices for void applications. It kills populations in walls and voids and creates a repellent, hostile environment which reduces the likelihood of bed bugs traveling through voids to other areas. Use a small hand type duster to "puff" insecticidal dusts into these areas. A light coating is all that is needed. To much dust and the bed bugs will just crawl around it.
Bed Bugs can re-infest your freshly treated bed, so be sure to stop them from crawling up the bed posts by using Climb-Up Bed Bug Insect Interceptors. The Climb-Up Insect Interceptor is a small dish that is placed under the bed post and captures bedbugs in a a powder coated ring. These type of bed bug traps are very effective and should be used on every bed to help make a complete bed bug proof bed.
"In the past, bedbugs have repeatedly shown the ability to develop resistance to products overly relied upon for their control. The findings of the current study also show similar trends in regard to chlorfenapyr and bifenthrin resistance development in bedbugs," study researcher Ameya Gondhalekar, research assistant professor at Purdue's Center for Urban and Industrial Pest Management, said in the Entomology Today statement. "With these findings in mind and from an insecticide resistance management perspective, both bifenthrin and chlorfenapyr should be integrated with other methods used for bed bug elimination in order to preserve their efficacy in the long term."

Treat other areas in your home.  This is perhaps the most challenging part of do-it-yourself bed bug control.  If you catch an infestation early you may not need to do anything more than treat and isolate your bed as described above.  But if an infestation has spread to other parts of the home, bed isolation may not be good enough. Here is where professional help may be needed, especially if you’re not up to moving furniture. Still determined?  Here are some tips that may improve your chances of success:


Treatment for bedbug bites is typically supportive. Local antiseptic lotions or antibiotic creams can be applied for secondary infections, whereas corticosteroid creams and oral antihistamines can be used for allergic reactions. Bedbugs can be eliminated through the use of permethrin insecticides, baited traps, special bedbug-free beds, and bed nets. Homemade methods, such as wrapping duct tape around bed legs as shown, may be effective, but bedbugs have been known to climb other objects and then fall down onto a bed. Image courtesy of Wikimedia Commons.

We recommend spraying Steri-Fab in areas where live bed bugs are visible. Steri-Fab combines a synthetic pyrethroid insecticide and isopropyl alcohol to kill bed bugs fast on contact. Steri-Fab also acts as a sanitizer. Steri-Fab does not leave any residual, meaning it can be applied virtually anywhere. Simply shake well, then apply to desired treatment areas. Insect mortality is imminent, generally within 10 minutes of spraying.
Some oils like tea tree and neem oil can't kill bedbugs, but they work well to repel them. Tea tree oil is an extract from the Melaleuca alternifolia plant—it can cause various health problems with pet birds, cats, and small dogs. If there are pets in the house, look for other safer choices. If you use the oil, apply it in small quantities to the skin to repel bed bugs. Since bed bugs are active at night, apply it before bedtime.
Susceptibility to arthropod bites depends on many external factors, such as occupation, conditions of employment, cohabitation with a variety of domestic animals, housing, climate, and clothing. An arthropod is usually attracted to its host by body heat, carbon dioxide in exhaled air, vibration, human sweat, and/or odor. The Cimex (bedbug) genus attacks both mammals and birds. C hemipterus (the tropical bedbug) bites mostly humans and is found in warm climates, whereas C lectularius (the common bedbug) also attacks bats and domestic animals, such as chickens.

The bites themselves don't usually pose any major health risk since bedbugs are not known to spread diseases, but an allergic reaction to the bites may require medical attention, CDC officials say. There have also been some strange cases linked to bedbug infestations. Researchers reported in the Canadian Medical Association Journal in 2009 that they treated a 60-year-old man for anemia caused by blood loss from bedbug bites. Another study published in 1991 in the Journal of the Egyptian Society of Parasitology found that people with asthma might be more susceptible to allergic reactions from bedbug bites.

Bed bug eradication is challenging and it’s prudent to hire a professional when resources allow. However treatment can be expensive, often costing hundreds or thousands of dollars. Those who cannot afford this often must cope with the problem themselves. A useful step that anyone can take to combat bed bugs is to install bed encasements. Covering the mattress and box spring can help eliminate a substantial portion of the bed bug population -- especially if discovered early while most of the bugs are still confined to the bed area. Extra care should be taken when installing budget encasements since these can tear easily, especially on metal bed frames. Ideally both the mattress and box spring should be encased. If only one encasement is possible it’s often best to cover the box spring which is harder to subsequently inspect.
Wash the bites with soap and water. Wash the area with mild soap and water; use a bar of soap and enough water to wet surface of your hands. Work the soap in your hands into thick, soapy lather. Rub the lather over the affected area liberally. Repeat until the entire area is covered. Leave on and do not rinse. Allow the soap lather to dry over the bitten areas. You should experience immediate relief from itching.[5] 

Bring in only what is needed, and avoid sitting or placing coats and other items on beds, floors and sofas where the bugs commonly reside. Essential items can be placed on a tabletop or other hard surface, preferably away from bedrooms and sleeping areas. Better to sit on a hard (non-upholstered) chair than on sofas and recliners. Also try to avoid leaning or brushing against beds and upholstered furniture. If such items are carried out of infested dwellings (e.g., by sanitation workers or firefighters), it’s best to wrap them in plastic or at least not hold them against your body during transport. Emergency Medical (EMS) personnel may need to take additional precautions, such as removing a patient’s bed bug-infested shoes or clothing, or installing plastic sheeting before transporting them in the emergency vehicle.    
While encountering bed bugs in hotels is possible, typically only a small number of rooms have problems. If bed bugs are discovered, guests can request another room, preferably in another area of the building, since problems often extend to nearby units. Should you experience itchy welts suggestive of bed bug bites during your stay, it would be prudent upon returning home to place all clothing directly into the washer and/or dryer. Inspecting or vacuuming luggage upon arrival home is less useful since it’s hard to spot bed bugs inside a suitcase. The suitcase itself can either be treated or discarded. 
First off you should ALWAYS go to pest control if you think you have bedbugs! You shouldn’t try and get rid of them yourself, 99% of the time it does not work. Plus even if you removed infected areas and wash them it wouldn’t kill the eggs. Plus bedbugs are very easy to get but very hard to get rid of. So you should never do it yourself it won’t work!
Bed bugs are attracted to their hosts primarily by carbon dioxide, secondarily by warmth, and also by certain chemicals.[4][16][17][18] Cimex lectularius only feeds every five to seven days, which suggests that it does not spend the majority of its life searching for a host. When a bed bug is starved, it leaves its shelter and searches for a host. It returns to its shelter after successful feeding or if it encounters exposure to light.[19] Cimex lectularius aggregate under all life stages and mating conditions. Bed bugs may choose to aggregate because of predation, resistance to desiccation, and more opportunities to find a mate. Airborne pheromones are responsible for aggregations.[20]
Stripping and vacuuming the mattresses and box springs, and encasing them.  Double bag your bedding and wash in hot water and dry for at least 30 minutes (discard the inner bag after putting bedding into the washer, as it could have bed bugs).  After vacuuming suspected bed bugs from the bed, take your vacuum cleaner outdoors and remove and discard the bag.  Purchase a good quality set of bed-bug-proof encasements for your mattresses and box springs. Bed bug-proof encasements are fabric sacks into which you slide your mattress or your box spring. The zippers on bed bug encasements are designed to be tight enough to prevent even the smallest life stages of the bed bugs from escaping. Also, good bed bug-proof encasements are woven to prevent bed bugs from biting you through the encasement. A good encasement will trap all bed bugs in the mattress and box spring inside, and will be smooth on the outside, providing few places for bed bugs to hide. Sears, Target, Walmart and other stores may sell bed bug-proof encasements, but these can also be purchased online. A good place to look for different brands and reviews of mattress encasements is Amazon.com (whether you buy there or at a local store). Go to http://www.amazon.com and search for “bed bug mattress protectors”.
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