First up is the most commonly recommended tool by far: rubbing alcohol diluted in water. This is suggested because alcohol can kill bed bugs on contact, and evaporates shortly after, so it’s considered safe for use pretty much anywhere in a home. A recurring theme in these recommendations are household items that are considered to be safer for people than mainstream chemicals.
Check to see if you can identify the rust-colored fecal stains, egg cases, and shed skins (exuviae) in crevices and cracks on or near beds. A sweet, musty odor is sometimes present. You should also look at other areas such as under wallpaper, behind picture frames, in couches and other furniture, in bedsprings and under mattresses, and even in articles of clothing. While fecal stains and skin casts suggest that bedbugs have been present, these do not confirm that the infestation is still active. Observing the bedbugs themselves is definitive confirmation that an area is infested. You may require professional assistance from a pest-control company in determining whether your home has a bed bug problem.
Treat other areas in your home. This is perhaps the most challenging part of do-it-yourself bed bug control. If you catch an infestation early you may not need to do anything more than treat and isolate your bed as described above. But if an infestation has spread to other parts of the home, bed isolation may not be good enough. Here is where professional help may be needed, especially if you’re not up to moving furniture. Still determined? Here are some tips that may improve your chances of success:
Checking beds for bed bugs was a common practice long ago, especially while traveling. Travelers today should consider doing the same, preferably before unpacking. This would entail examining the bed sheets and seams of the mattress and perhaps box spring for signs of bed bugs, especially along the head (pillow end) of the bed. Experts also remove and check behind headboards since this is a frequent hiding place for bed bugs in hotels. Headboards are heavy and cumbersome, however, and untrained persons should not attempt removal themselves.
Scrub infested surfaces with a stiff brush to dislodge eggs. Vacuum the room extensively. Use a vacuum hose attachment to thoroughly vacuum cracks and crevices on furniture and along baseboards on the walls. Vacuum along baseboards, furniture, bed stands, rails, headboards, foot boards, bed seams, tufts, buttons, edges of the bedding, as well as the edges of the carpets (particularly along the tack strips). A good vacuum cleaning job may remove particles from cracks and crevices to encourage greater insecticide penetration. Bed bugs cling tightly to surfaces, so it is best to vacuum by scraping the end of the vacuum attachment over the infested areas to pull out the bed bugs. Caution: It is not good to use a bristle attachment, because you may transfer bed bugs to other areas since they cling to the brush. Dispose of vacuum cleaner bags after you are finished in an outdoor trashcan.
It is hard to tell if you’ve been bitten by a bed bug unless you find bed bugs or signs of infestation. When bed bugs bite, they inject an anesthetic and an anticoagulant that prevents a person from realizing they are being bitten. Most people do not realize they have been bitten until bite marks appear anywhere from one to several days after the initial bite. The bite marks are similar to that of a mosquito or a flea — a slightly swollen and red area that may itch and be irritating. The bite marks may be random or appear in a straight line. Other symptoms of bed bug bites include insomnia, anxiety, and skin problems that arise from profuse scratching of the bites.
Bed bugs like to travel and are good hitchhikers. They will hide in suitcases, boxes and shoes to be near a food supply. They are elusive, nocturnal creatures. They can hide behind baseboards and in cracks, crevices, and folded areas of beds, bedding and adjacent furniture, especially mattresses and box springs. Bed bugs can also hide in electrical switchplates, picture frames, wallpaper and nearly anywhere inside a home, car, bus, or other shelter. Bed bugs usually come out at night for a blood meal. However, they are opportunistic insects and can take a blood meal during the day, especially in heavily-infested areas. Bed bugs usually require 5-10 minutes to engorge with blood. After feeding, they move to secluded places and hide for 5-10 days. During this time in the bed bug life cycle, they do not feed but instead digest their meal, mate, and lay eggs.
To begin, strip your bed of all sheets, pillowcases, and other bedding, and seal them in plastic garbage bags to keep bed bugs from escaping and infesting other parts of your home. Take the bags straight to the washing machine, and wash them using the hot water setting. Then, dry the bedding on high heat if their tags allow it. This heat treatment will kill any bed bugs or eggs hiding in your bedding.
Other types of bed bug traps include those that do not rely on humans as bait, but instead use CO2and/or other attractants. CO2 is thus far the most powerful lure for bed bugs, as it is the primary cue they follow to locate hosts. Traps that issue CO2 for a period of time are more expensive than Climbup™ traps, but can effectively trap bed bugs when no host is present, such as in common areas, vacant homes or units, offices, schools, and theaters. Thus they can help confirm infestation and eradication.
Check the mattress throughly, paying close attention to seams and tufts along the edges. Flip the mattress over and inspect the bottom carefully as well. Pay particular attention to any rips in the fabric. View the fabric on the bottom of the box spring and shine a flash light to verify that bed bugs have not penetrated the interior of the box spring.
Turns out, C. lectularius is also forming a resistance to other insecticides, according to a study published online April 10, 2017, in the Journal of Economic Entomology. The researchers, from Purdue University, found that three out of 10 bedbug populations collected in the field showed much less susceptibility to chlorfenapyr, and five of the 10 populations showed reduced susceptibility to bifenthrin, according to a post on Entomology Today. The scientists defined "reduced susceptibility" as a population in which more than 25 percent of the begbugs survived after seven days of exposure to the particular insecticide.
New tactics may be needed for this escalating public health concern in locations with high occupant turnover, such as hotels, hospitals, and nursing homes.  Indeed, in the past decade bedbugs have become a worldwide urban pest, with the number of American households affected markedly increased.  Genetic data suggest that C lectularius may be undergoing lineage divergence through host association. 
While most of the bed bugs were wiped out by the chemicals, three groups continued to thrive after being treated with chlorfenapyr, and five groups were still kicking after being treated with bifenthrin. That means that while some bed bugs will respond to these chemicals, others won't—and it's likely that more and more bugs will become resistant over time.
While alcohol can kill bed bugs on contact, it’s not going to kill nearly enough of bed bugs to be considered effective. In lab studies, even 99 percent concentrations of alcohol only killed between 40% to 60% of the adults that were sprayed. On top of that, alcohol has no long-lasting residual effect, and doesn’t affect bed bug eggs. 60% sounds good, but a contact killer should be able to kill a lot closer to 100% of the bed bugs you see. Otherwise, a shoe or a blowtorch would be the more reliable tool for the job. (Editor’s note: please don’t use a blowtorch.)
The exact causes of this resurgence remain unclear; it is variously ascribed to greater foreign travel, increased immigration from the developing world to the developed world, more frequent exchange of second-hand furnishings among homes, a greater focus on control of other pests, resulting in neglect of bed bug countermeasures, and increasing resistance to pesticides. Declines in household cockroach populations that have resulted from the use of insecticides effective against this major bed bug predator have aided the bed bugs' resurgence, as have bans on DDT and other potent pesticides.[medical citation needed]
If you arrive home and discover that you have brought some unwanted guests home with you, immediately notify the hotel of your discovery. Having a possible infestation in hotels and motels can be a public relations nightmare for the owners. Politely ask them to pay for any and all costs incurred to rid your clothing and home of a possible new infestation.