Bed bugs are highly vulnerable to heat; exposing them to a certain amount of direct heat will kill them instantly, while lower temperatures can kill them in a matter of minutes. This is why many forms of heat treatments are recommended. Some methods, such as steamers and portable heaters, have been proven effective through professional use and are quickly becoming standard issue in holistic treatment arsenals.
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Ticks are known transmitters of disease to humans and animals. Tick-borne diseases include Lyme disease, Rocky Mountain spotted fever, Q fever, tularemia, babesiosis, and Southern tick-associated rash illness. Infected ticks spread disease once they've bitten a host, allowing the pathogens in their saliva and mouth get into the host's skin and blood. Tick bites are typically painless, but the site of the bite may later itch, burn, turn red, and feel painful. Individuals allergic to tick bites may develop a rash, swelling, shortness of breath, numbness, or paralysis. Tick bite treatment involves cleaning and applying antibiotic cream.
Skin reactions from bed bug bites vary from person to person. Bites may go unnoticed or may be mistaken for flea or mosquito bites or other skin conditions. The most common skin reaction to bed bug bites are itchy red bite marks that appear clustered or in a straight line, often along the edge of clothing or where sheets were pulled up to a person's skin. Small swollen red bumps are also common. In rare cases, people may develop large, often itchy, red welts. A single bed bug bite is similar to a flea bite, except that a red area does not occur in the center. Flea bites tend to be found around the ankles while bed bugs tend to bite any exposed area of the body while a person is sleeping, such as the face, neck, arms, hands, or legs.
Treat or isolate your bagged items. For washable items research shows that dry cleaning, washing in hot water for 30 minutes, or tumble drying for 30 minutes on high will kill all stages of bed bugs. Non-washables are a little trickier.  Items that aren’t needed for a while can just be stored. It takes 2-5 months to kill bed bugs by isolating them in bags (the warmer the temperature, the shorter the survival time for starving bed bugs). Heating bags by placing in direct sunlight is one of the most effective methods during the warm summer months.  Seven pounds of items placed in clear bags in direct sunlight on a 95 degree day will get hot enough to kill all bed bug life stages in one afternoon.  Also, placing bagged items in a chest freezer (0 degrees F) for 8-10 hours is lethal for bed bugs and their eggs. Some toys may be disinfested by cleaning with hot soapy water and/or rubbing alcohol.
A definitive diagnosis of health effects due to bed bugs requires a search for and finding of the insect in the sleeping environment as symptoms are not sufficiently specific.[5] Bed bugs classically form a line of bites colloquially referred to as "breakfast, lunch, and dinner" and rarely feed in the armpit or behind the knee which may help differentiate it from other biting insects.[4] If the number in a house is large a pungent sweet odor may be described.[4] There are specially trained dogs that can detect this smell.[2]
The life cycle stages of a bed bug are egg, nymph, and adult. The reason they are called bed bugs is that they readily infest mattresses, bed frames and box springs. Eggs are laid along the edges of or around buttons on the mattresses. Eggs can also be glued to rough surfaces. Bed bug females lay about 200 eggs, usually at the rate of three or four a day. Eggs are placed in cracks, crevices and other isolated and protected shelters. Females lay eggs after a blood meal. Eggs will hatch in one or two weeks into Nymphs. Newly hatched bugs (Nymphs) begin feeding immediately. At room temperature, and with an available food supply, the nymphal period will last 14 to 30 days. They shed their skin (Instar) five times before becoming adults. Bed bugs will mate soon after becoming mature, so the time from egg hatch to egg laying is 4 to 9 weeks, under favorable conditions. The average life span of the bed bug is 6-12 months and they feed every 10 days or so during this time. Bed bugs can survive many months without a blood meal and their reproduction is high.

Skin reactions from bed bug bites vary from person to person. Bites may go unnoticed or may be mistaken for flea or mosquito bites or other skin conditions. The most common skin reaction to bed bug bites are itchy red bite marks that appear clustered or in a straight line, often along the edge of clothing or where sheets were pulled up to a person's skin. Small swollen red bumps are also common. In rare cases, people may develop large, often itchy, red welts. A single bed bug bite is similar to a flea bite, except that a red area does not occur in the center. Flea bites tend to be found around the ankles while bed bugs tend to bite any exposed area of the body while a person is sleeping, such as the face, neck, arms, hands, or legs.
Reality: Bedbug control can only be maintained through a treatment strategy that includes a variety of techniques plus careful attention to monitoring. Proper use of pesticides may be part of the strategy, but will not by itself eliminate bedbugs. In addition, bedbug populations in different areas of the country have developed resistance to the ways many pesticides work to kill pests. If you're dealing with a resistant population, some products and application methods may not work. It is a good idea to consult a qualified pest management professional if you have bedbugs in your home.
Bedbug bites, like all insect bites, can become infected through excessive scratching, as underneath the fingernails lies a host of bacterial pathogens. If your bites become infected, they will appear red and swollen, feel tender and may drain pus. Typically there will not be a fever unless a substantial area of the skin is involved. If you experience any of these symptoms, you must seek medical attention as it points to a secondary infection. Your physician may prescribe antibiotic therapy or, if the infection is mild, an antiseptic medication that you can buy without a prescription.[12][13][14]
Treat mattress box spring and furniture voids with Cimexa Dust or Delta Dust. Turn bed box springs over and remove the cloth cover seal. Thoroughly inspect and treat the box springs area with insecticidal dust. After treatment replace the cloth cover seal with staples or screws. Hollow bed-frames, platforms, headboards and any other voids discovered during inspection should also be treated where possible. The upper mattress can be sprayed and treated with Bedlam Plus, Zenprox or Sterifab.
"By every metric that we use, it's getting worse and worse," says Coby Schal, an entomologist at North Carolina State University in Raleigh. Health authorities and pest control operators are regularly flooded with calls, and the epidemic may not have yet peaked. And because bedbugs are indoor pests, there are no high or low seasons throughout the year, he adds, only continual bombardment. "It's just the beginning of the problem in the U.S.," Schal says.
Some preparation is still required (e.g. removal of heat-sensitive items such as aerosol cans, indoor plants and medications), but it is seldom necessary to bag, launder and/or hot dry bedding and clothing since these items will be heated along with other furnishings. Another advantage of heat treatment is that infestations can often be eliminated in one day, rather than over multiple days or weeks. Conversely, heat treatment alone has no lasting (residual) effect should bed bugs be reintroduced into the dwelling. Consequently, some companies recommend concurrently applying residual insecticides. To further minimize reintroduction, occupants are advised to take as few belongings as possible with them while the heat treatment is in progress.    
Determine which rooms are infested. Bedrooms are the principal locations for bed bugs; however, any room where people sleep in the home may provide harborage for bed bugs. Living rooms with sofas and sofa beds are the next most common sites for bed bugs. Typically an infestation starts in one room and spreads slowly to other places where people sleep.  The sooner you find and treat bed bugs the easier it will be to get rid of them.  Wait too long and bed bugs may be found throughout your home.
Instead, get written quotes from three licensed exterminators detailing their course of action, including pesticides, traps, and/or heat treatments they'll use and how and where they'll use them. "You should ask lots of questions to the companies you interview, because a good company will answer them and will never pressure you to make an appointment," says Dunham.
Cracks and crevices of bed frames should also be examined, especially if the frame is wood. (Bed bugs have an affinity for wood and fabric more so than metal or plastic.) Wooden support slats, if present, should be removed and examined since bed bugs often congregate where the ends rest on the frame. Screw holes, knots and other recesses are also common hiding places. Headboards secured to walls should be removed and inspected. In hotels, the area behind the headboard is often the first place that bed bugs become established. Bed bugs also frequently hide within items stored under beds. 
The first sign of a bed bug problem is obvious: the bed. After bed bugs feed on humans, they'll leave behind blood stains resembling small rust spots. These will usually be found near the corners and edges of the bed. Bed bugs also shed their skin, or molt, several times as they mature, so you may find their oval brown exoskeletons during your search.
CrossFire Bed Bug Concentrate has two different active ingredients for dual modes of action (both a quick kill and residual activity). Mix 3 oz of CrossFire Insecticide with one gallon of water or 0.75 oz per quart (Remember to use what you mix-within 24 hours.) Adjust the spray pattern to a mist by turning the nozzle. A low fine mist is best for most spraying, but you may need to use a stream to get into some cracks and crevices. If you can't get into the cracks and crevices use one of the aerosols described below with it's crack and crevice tips to reach into these areas.
Thanks to pesticide resistance, those cans of spray at your local hardware store simply will not do, Schal says, adding: "Relying strictly on chemicals is generally not a good solution." The most effective solutions are fumigation and heat treatments, but these can cost a cool $2,000 to $3,000 apiece for a single-family home. Scientists are diligently pursuing other strategies, including freezing and bait similar to that used for cockroaches. In the October 2010 issue of the Journal of Economic Entomology Schal and colleagues at the U.S. Department of Agriculture published a technique that employs inexpensive infrared and vibration sensors to track bedbug movement, which could be applied to the development of automated traps that detect the pests.
Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.
If you arrive home and discover that you have brought some unwanted guests home with you, immediately notify the hotel of your discovery. Having a possible infestation in hotels and motels can be a public relations nightmare for the owners. Politely ask them to pay for any and all costs incurred to rid your clothing and home of a possible new infestation.
Bed bugs were mentioned in ancient Greece as early as 400 BC, and were later mentioned by Aristotle. Pliny's Natural History, first published circa AD 77 in Rome, claimed bed bugs had medicinal value in treating ailments such as snake bites and ear infections. (Belief in the medicinal use of bed bugs persisted until at least the 18th century, when Guettard recommended their use in the treatment of hysteria.[51])
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