Treatment is symptomatic.[2] Eliminating bed bugs from the home is often difficult, partly because bed bugs can survive up to a year without feeding.[2] Repeated treatments of a home may be required.[2] These treatments may include heating the room to 50 °C (122 °F) for more than 90 minutes, frequent vacuuming, washing clothing at high temperatures, and the use of various pesticides.[2]
Use of Organic-Based Bed Bug Spray – thanks to growing going green trend, there are now bed bug products made with natural ingredients. With them, you could now get rid of the crawlies safely, easily and inexpensively. However, you should take note that this method only works if you have the best-selling bed bug spray that kills on contact and is without harsh chemical ingredients. 

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: University of Alabama at Birmingham; University of Alabama Health Services Foundation
Serve(d) as a speaker or a member of a speakers bureau for: Ferndale Laboratories
Received research grant from: NIH, Veterans Administration, California Grape Assn
Received consulting fee from Astellas for review panel membership; Received salary from Massachusetts Medical Society for employment; Received salary from UpToDate for employment. for: Astellas.

If you live in an apartment or condominium, it’s best to alert the property manager.  A coordinated bed bug control effort using a pest control company is generally needed in such situations. Bed bugs readily move from apartment to apartment, with many people unaware that they have a problem. If one apartment is infested, adjoining units (left side, right side, above and below) should be assumed to be infested unless shown otherwise through inspection or monitoring.  Simply asking tenants whether they have bed bugs is not enough.  In one recent study only half of apartment residents whose homes were determined to have bed, bugs knew (or admitted) they had a bed bug problem.

Insecticides might also have their work cut out for them: Entomologists have known that the common bedbug has built up resistance to some typical insecticides such as those containing certain pyrethroid chemicals like deltamethrin, according to Entomology Today. Deltamethrin apparently paralyzes an insect's nervous system, according to Cornell University.
Move your bed away from any other points of contact, like walls, nightstands, and other furniture. Tuck in or remove any hanging skirts or sheets, and remove any storage under the bed that is touching any part of the frame. The only thing your bed should be touching is the floor via its legs. If you don’t have a bed frame with legs, you should purchase one to sleep in, at least until you are bed bug free.

Bed bug eradication is challenging and it’s prudent to hire a professional when resources allow. However treatment can be expensive, often costing hundreds or thousands of dollars. Those who cannot afford this often must cope with the problem themselves. A useful step that anyone can take to combat bed bugs is to install bed encasements. Covering the mattress and box spring can help eliminate a substantial portion of the bed bug population -- especially if discovered early while most of the bugs are still confined to the bed area. Extra care should be taken when installing budget encasements since these can tear easily, especially on metal bed frames. Ideally both the mattress and box spring should be encased. If only one encasement is possible it’s often best to cover the box spring which is harder to subsequently inspect.
Use precautions in your own home. Keep the plastic covering that comes on your mattress when purchased new. Purchase special bedbug covers for you mattress and box spring. Make sure that they are quality ones with heavy duty zippers and constructed with special fabric that doesn't rip easily. Don't buy the cheap versions which are not thick enough to prevent the bedbugs from sticking their feeding tubes into the skin through the cover.[19]
The scientific name for bed bugs is Cimex lectularius. They are small creatures that grow up to 5 mm in size, or about the size of an apple seed. They have a flat oval-shaped body and will become significantly larger if they have fed. According to the United States Environmental Protection Agency, bed bugs start life as a tiny egg, then grow into a nymph before becoming an adult.1
Bedbugs normally feed at night, usually approximately 1 hour before dawn. However, if the conditions are favorable, they also feed during the day. Feeding takes 3-12 minutes. In proper conditions, adult bedbugs can survive without a meal for 1 year or longer. Each female lays approximately 300 eggs in her lifetime. The eggs hatch in 10 days. The nymph stage lasts 6 weeks, undergoing 5 molts.
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Stripping and vacuuming the mattresses and box springs, and encasing them.  Double bag your bedding and wash in hot water and dry for at least 30 minutes (discard the inner bag after putting bedding into the washer, as it could have bed bugs).  After vacuuming suspected bed bugs from the bed, take your vacuum cleaner outdoors and remove and discard the bag.  Purchase a good quality set of bed-bug-proof encasements for your mattresses and box springs. Bed bug-proof encasements are fabric sacks into which you slide your mattress or your box spring. The zippers on bed bug encasements are designed to be tight enough to prevent even the smallest life stages of the bed bugs from escaping. Also, good bed bug-proof encasements are woven to prevent bed bugs from biting you through the encasement. A good encasement will trap all bed bugs in the mattress and box spring inside, and will be smooth on the outside, providing few places for bed bugs to hide. Sears, Target, Walmart and other stores may sell bed bug-proof encasements, but these can also be purchased online. A good place to look for different brands and reviews of mattress encasements is Amazon.com (whether you buy there or at a local store). Go to http://www.amazon.com and search for “bed bug mattress protectors”.
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