Bedbug infestations affect both sexes and people of all ages and races in the United States and globally, particularly in poor regions of the world.  The reported rate of bedbugs (Cimex hemipterus) was 37.5% in children's beds from a rural region of Gambia. Recently, bedbugs were allegedly reintroduced from abroad into Seoul, Korea, because there had been no reports on bedbugs in Seoul for more than 20 years. 
Don't let the name bedbug fool you. Bedbugs can be found any place humans rest and lounge and nearby. Bedbugs can be found under school desks, restaurant benches, on computers in the library, chairs, hospital beds and curtains or on a store wall. The same goes for carpets. Many times a brush against a wall in on infested area can lead to bedbugs in the home. Bedbugs are very good at clinging onto fabrics. Transportation hubs such as airports, train stations and bus terminals are also key infestation stations to be wary of.
Because their bodies are flat, they can hide under the smallest spots like the border of beds, under the mattress, edges of carpets, couches, cracks in the walls and ceilings, in your pillows, under your bed sheets, behind electrical plugs and wall sockets, in your cupboards and dressers, or under furniture. In fact, bed bugs prefer any fabric materials. They can travel pretty good distances, too. Expect them to be able to be found anywhere in the room.
The mechanism of skin injury by arthropods depends on the structure of the mouthparts. These insects are categorized as vessel feeders if they insert the tip into a capillary or as pool feeders if they feed on the extravasated blood from damaged tissue. They often inject different pharmacologically active substances (eg, hyaluronidase, proteases, kinins), which may cause different skin reactions (eg, erythema, wheal, vesicle, hemorrhagic nodule). See the following images.
Doctors often misdiagnose those afflicted because it is nearly impossible to tell, if you are experiencing an allergic reaction, what bit you. Often healthcare providers and individuals that have been bitten by a member of the Hemiptera order mistake bites for those of a mosquito. The only way to discern, with complete surety, what your bites are from, is to get a sample of what has bitten you.
To treat an allergic reaction, the doctor may prescribe an antihistamine, corticosteroid, or epinephrine injection. If the area is infected, he or she might prescribe an antibiotic or recommend an over-the-counter antiseptic. Finally, if it’s severe itchiness that you’re dealing with, applying corticosteroid or taking an antihistamine in pill or liquid form may be able to help.
Did you or someone else in your home recently come home from a trip? Bugs can stow away in clothing and in the recesses of your luggage. A good preventative measure is to check lodging you are staying in immediately after arrival. As mentioned before, signs are evident, even during the daytime, include the blood-colored excrement they leave behind.
Next, apply a bed bug powder into confined areas where it won’t be stirred up into the air. Places like the edges of carpeting, inside deep cracks and wall voids, and inside electrical outlets and light switches (accessed by removing the faceplate with a screwdriver) are good candidates for powders, as sprays can’t reach into these areas quite as well. We recommend using a professional powder applicator, which offers better control when applying the powder.
You should look for traces of the insects in the folds of your mattresses, box springs and other places where they are likely to hide. You might be able to find their papery skins, which get cast off after molting and look like popcorn kernels but are smaller and thinner, Harlan said. They also leave small, dark-colored spots from the blood-filled droppings they deposit on mattresses and furniture. If you can touch the spot with a water-soaked towel and it runs a rusty, reddish color, you're probably looking at a fresh drop of bedbug feces, Harlan said.
Mix 3 oz per gallon or 0.75 oz per quart and spray with a low pressure sprayer into the areas where the bed bugs are hiding. Typical areas include bed frames, headboards, under beds, baseboards, moldings, behind pictures,etc. Remember to apply in the joints and crevices of furniture. If the crack and crevice is too small, use an aerosol with a crack and crevice tip (recommendations are below.)
Bed bugs are very hardy insects. Both adults and nymphs can survive prolonged periods without food or under adverse temperature conditions. Adults can live for a year or longer without feeding and can survive over winter in an unheated building. Nymphs are not as hardy as adults, but they can survive for considerable periods under adverse conditions.
Flat surfaces can be wiped with alcohol or sprayed with a bed bug—killing contact pesticide, but all items that have a small nook or cranny where bed bugs could hide (which is most stuff) need to be treated with penetrating fumes. Build yourself a kill chamber out of a large storage bin. Tape a pesticide strip to the side or lid of the bin, and seal your stuff inside for a couple days or however long the manufacturer recommends. Seal the lid of the bin with duct tape.
Now that you’ve killed the bed bugs hiding in your bed, it’s time to put up defensive measures to keep them out. Remember, bed bugs can be hiding in all sorts of cracks and crevices throughout your bedroom – in furniture, along baseboards, and inside of the walls – so you need a way to keep them out of your freshly treated bed. By cutting off the infestation’s food supply (you), you halt their breeding and reproductive cycle, making the treatment a whole lot easier.
Encase Mattresses and use bed bug interceptor traps on bed frames. After everything is put back and all pesticides are dried, vacuum the area again to remove any dead or dying bedbugs and to pick up any spilled dust or pesticide. Be sure to throw the vacuum cleaner bag away outdoors. A thorough treatment is essential to achieve adequate control. It is usually desirable to apply insecticides for bed bugs early in the day, so that insecticide spray residues will have several hours to dry, or dusts will have time to settle, before the room will be used again for sleeping. As a safety consideration it is particularly important to dry and cover mattresses completely before they are reused. A mattress encasement such as The Elite Zippered Mattress and Boxspring Encasement should be used to cover and conceal the mattress and the boxsprings. It is important to use a quality zippered encasement (cover) with a special zipper closure to make sure that bedbugs do not crawl out of the zipper opening.
Bites on dogs and cats will look much like bites on people, and the pet owner may actually suspect a mosquito or flea bit the pet. As with people, bed bugs do not stay on pets, but return to a protected harborage site after feeding. In addition to bites, the presence of the bug’s feces, cast skins and the animal’s irritation at night are also indicators of bed bugs biting pets. Therefore, one of the best things to do is inspect the pet’s bedding and frequently groom the animal while being vigilant for the telltale signs of bed bug presence.
Minimize its spread. First, notify your landlord if you rent in a building to control its spread to other units. Thoroughly vacuum any infested areas, including carpets and mattresses, and then empty the vacuum bag into a plastic bag, seal it, and throw it in the trash outside. If you can’t get the bed bugs out of your furniture, discard items in a responsible manner. To avoid someone else from salvaging infested furniture or mattreses, rip, remove stuffing, or spray paint with the words “bed bugs.”
Once the mattress and box spring are dry, encase them in sealed bed bug encasements. Encasements are crucial, as they prevent bed bugs from entering or escaping the mattress and box spring, cutting off key hiding places. Remember to leave the encasements on for at least 18 months to ensure that any bed bugs already inside have starved to death. Once the encasements have been applied, you can put your mattress and box springs back on your treated bed frame, and put your laundered bedding back on your bed.
Reactions to bed bug bites vary among individuals. Many persons show no signs of bites. Others don’t realize they’ve been bitten until redness and swelling appear around the bite, sometimes with intense itching. Some exhibit inflamed swollen spots that may occur in linear series or have a rash-like appearance. Such bite marks, when they appear, may not show for several days after the person is bitten.