When the controversial pesticide DDT was banned in 1972, most bed bugs were already resistant to it, Schal says, and today's populations are even more widely resistant thanks to the use of a new class of pesticides. Pyrethroids, the main class of pesticides used against bedbugs today, targets sodium channels in bedbug cells, just like DDT. Consequently, as bedbugs develop resistance to pyrethroids, they also become cross-resistant to DDT.
While your laundry cycle is running, use a vacuum cleaner to remove any bed bugs, shells, fecal droppings, or eggs that might be along the seams of your mattress, pillows, box spring, and along the cracks and crevices in the bed frame, headboard, and footboard. Follow up the vacuuming with a high pressure steamer to penetrate deep inside mattresses, box springs, bed frames, headboards, and footboards to kill bed bugs and eggs on contact.
With the bed now fully isolated and elevated, bed bugs hiding elsewhere in the room won’t be able to feed on you or hide in your bed. You can also use the ClimbUps to monitor the changing population of bed bugs in your home. Hopefully, you will see less and less bugs appear in the traps as you go through the next steps. Now that you have created a safe haven in your bed, you can move on to treating the rest of the room.
Use of Organic-Based Bed Bug Spray – thanks to growing going green trend, there are now bed bug products made with natural ingredients. With them, you could now get rid of the crawlies safely, easily and inexpensively. However, you should take note that this method only works if you have the best-selling bed bug spray that kills on contact and is without harsh chemical ingredients.
Probably chiggers -- they are very small, red mites that usually cannot be seen with the naked eye. They are about as small as the period at the end of this sentence. To stop the itching, use OraJel (usually sold for teething babies), which contains benzocaine (an anesthetic). Also, rub in hydrocortisone cream. To prevent chigger bites, wear long pants and stuff the cuffs into your socks.
Never treat any bedding, mattress, etc. with anything other than the treatments listed: borax, enzyme cleaner, Comet, sodium borate. Other pesticides and exterminating fluids can be harmful to humans. Even so, bedding and mattresses treated with chemicals such as borax or Comet should be left outside to dry naturally in the sun, then wrapped in plastic before next use, so as not to irritate the skin.
Insecticides might also have their work cut out for them: Entomologists have known that the common bedbug has built up resistance to some typical insecticides such as those containing certain pyrethroid chemicals like deltamethrin, according to Entomology Today. Deltamethrin apparently paralyzes an insect's nervous system, according to Cornell University.
If a trap method does not effectively stop bed bugs, then I wouldn’t consider it. Instead, I would recommend a set of ClimbUp Insect Interceptors. These are pitfall traps that go under the legs of your bed and trap bed bugs in a talcum-lined pitfall that is too slick and smooth for them to climb out of. ClimbUp Interceptors have been proven over the years to be effective, and are an essential part of our recommended treatment process.
Skin reactions from bed bug bites vary from person to person. Bites may go unnoticed or may be mistaken for flea or mosquito bites or other skin conditions. The most common skin reaction to bed bug bites are itchy red bite marks that appear clustered or in a straight line, often along the edge of clothing or where sheets were pulled up to a person's skin. Small swollen red bumps are also common. In rare cases, people may develop large, often itchy, red welts. A single bed bug bite is similar to a flea bite, except that a red area does not occur in the center. Flea bites tend to be found around the ankles while bed bugs tend to bite any exposed area of the body while a person is sleeping, such as the face, neck, arms, hands, or legs.
Bed bug bites are caused primarily by two species of the insect Cimex: Cimex lectularius (the common bed bug) and Cimex hemipterus.[3] Their size ranges between 1 and 7 mm.[7] They spread by crawling between nearby locations or by being carried within personal items.[2] Infestation is rarely due to a lack of hygiene but is more common in high-density areas.[8][2] Diagnosis involves both finding the bugs and the occurrence of compatible symptoms.[5] Bed bugs spend much of their time in dark, hidden locations like mattress seams or cracks in the wall.[2]
As mentioned earlier, applying insect repellent at bedtime will probably not deter bed bugs from biting. When working in severely infested dwellings, there may be some benefit to spraying tops and bottoms of shoes with DEET-based repellents. Those working in bed bug-infested environments may also want to hot wash or run clothing, etc. through a dryer upon returning home or to the office.    
Dogs have been sniffing out insects such as termites for many years, and are now being used as inspection tools for bed bug detection. But while companies using dogs may advertise them as being highly accurate in finding bed bugs, one should not get the impression that dogs are infallible or that they are in all ways superior to human inspectors. Research on the effectiveness of dogs as bed bug detectors suggests that for those who would employ dogs, the message is buyer beware. There appears to be great variance in the accuracy of bed bug dogs, and even well-trained dogs are subject to missing bed bugs and to giving “false positives” (signaling the presence of bed bugs where there are none).
Instead, get written quotes from three licensed exterminators detailing their course of action, including pesticides, traps, and/or heat treatments they'll use and how and where they'll use them. "You should ask lots of questions to the companies you interview, because a good company will answer them and will never pressure you to make an appointment," says Dunham.
Bed bug incidents in schools are best handled by knowledgeable pest control firms. Widespread insecticide treatment of classrooms, hallways, buses, etc. is unnecessary, ineffective and imprudent. Effort instead should be spent checking chairs, desks, lockers, coat rooms, etc. in the vicinity of where the bugs were found, and treatment should be focused on those specific areas. Canine inspections can also be useful in finding small numbers of bed bugs in schools and other establishments where there are no beds.      

Mechanical approaches, such as vacuuming up the insects and heat-treating or wrapping mattresses, are effective.[3][6] An hour at a temperature of 45 °C (113 °F) or over, or two hours at less than −17 °C (1 °F) kills them.[6] This may include a domestic clothes drier for fabric or a commercial steamer. Bed bugs and their eggs will die on contact when exposed to surface temperatures above 180 °F (82 °C) and a steamer can reach well above 230 °F (110 °C).[31][15] A study found 100% mortality rates for bed bugs exposed to temperatures greater than 50 °C (122 °F) for more than 2 minutes. The study recommended maintaining temperatures of above 48 °C (118 °F) for more than 20 min to effectively kill all life stages of bed bugs, and because in practice treatment times of 6 to 8 hours are used to account for cracks and indoor clutter.[32] This method is expensive and has caused fires.[6][15] Starving them is not effective as they can survive without eating for 100 to 300 days, depending on temperature.[6] One expert recommends not trying to get rid of bed bugs exclusively on one's own.[29]

Some bed bug species are parasites of bats or birds, and may bite people if the wild hosts are no longer available. Although similar in overall appearance, the species of bed bugs that normally feed on bats, swallows, chimney swifts, pigeons or other wild hosts can be differentiated from those that prefer humans. Entomologists and knowledgeable pest managers can make this determination. If bat bugs or bird bugs are present, roosting and nesting sites should be the primary focus, and the animals should be removed and excluded from the building.